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Effects of a single intraperitoneal administration of cadmium on femoral bone structure in male rats
BACKGROUND: Exposure to cadmium (Cd) is considered a risk factor for various bone diseases in humans and experimental animals. This study investigated the acute effects of Cd on femoral bone structure of adult male rats after a single intraperitoneal administration. METHODS: Ten 4-month-old male Wis...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179732/ https://www.ncbi.nlm.nih.gov/pubmed/21884588 http://dx.doi.org/10.1186/1751-0147-53-49 |
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author | Martiniaková, Monika Chovancová, Hana Omelka, Radoslav Grosskopf, Birgit Toman, Róbert |
author_facet | Martiniaková, Monika Chovancová, Hana Omelka, Radoslav Grosskopf, Birgit Toman, Róbert |
author_sort | Martiniaková, Monika |
collection | PubMed |
description | BACKGROUND: Exposure to cadmium (Cd) is considered a risk factor for various bone diseases in humans and experimental animals. This study investigated the acute effects of Cd on femoral bone structure of adult male rats after a single intraperitoneal administration. METHODS: Ten 4-month-old male Wistar rats were injected intraperitoneally with a single dose of 2 mg CdCl(2)/kg body weight and killed 36 h after the Cd had been injected. Ten 4-month-old males served as a control group. Differences in body weight, femoral weight, femoral length and histological structure of the femur were evaluated between the two groups of rats. The unpaired Student's t-test was used for establishment of statistical significance. RESULTS: A single intraperitoneal administration of Cd had no significant effect on the body weight, femoral weight or femoral length. On the other hand, histological changes were significant. Rats exposed to Cd had significantly higher values of area, perimeter, maximum and minimum diameters of the primary osteons' vascular canals and Haversian canals. In contrast, a significant decrease in all variables of the secondary osteons was observed in these rats. CONCLUSIONS: The results indicate that, as expected, a single intraperitoneal administration of 2 mg CdCl(2)/kg body weight had no impact on macroscopic structure of rat's femora; however, it affected the size of vascular canals of primary osteons, Haversian canals, and secondary osteons. |
format | Online Article Text |
id | pubmed-3179732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31797322011-09-25 Effects of a single intraperitoneal administration of cadmium on femoral bone structure in male rats Martiniaková, Monika Chovancová, Hana Omelka, Radoslav Grosskopf, Birgit Toman, Róbert Acta Vet Scand Research BACKGROUND: Exposure to cadmium (Cd) is considered a risk factor for various bone diseases in humans and experimental animals. This study investigated the acute effects of Cd on femoral bone structure of adult male rats after a single intraperitoneal administration. METHODS: Ten 4-month-old male Wistar rats were injected intraperitoneally with a single dose of 2 mg CdCl(2)/kg body weight and killed 36 h after the Cd had been injected. Ten 4-month-old males served as a control group. Differences in body weight, femoral weight, femoral length and histological structure of the femur were evaluated between the two groups of rats. The unpaired Student's t-test was used for establishment of statistical significance. RESULTS: A single intraperitoneal administration of Cd had no significant effect on the body weight, femoral weight or femoral length. On the other hand, histological changes were significant. Rats exposed to Cd had significantly higher values of area, perimeter, maximum and minimum diameters of the primary osteons' vascular canals and Haversian canals. In contrast, a significant decrease in all variables of the secondary osteons was observed in these rats. CONCLUSIONS: The results indicate that, as expected, a single intraperitoneal administration of 2 mg CdCl(2)/kg body weight had no impact on macroscopic structure of rat's femora; however, it affected the size of vascular canals of primary osteons, Haversian canals, and secondary osteons. BioMed Central 2011-08-31 /pmc/articles/PMC3179732/ /pubmed/21884588 http://dx.doi.org/10.1186/1751-0147-53-49 Text en Copyright ©2011 Martiniaková et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Martiniaková, Monika Chovancová, Hana Omelka, Radoslav Grosskopf, Birgit Toman, Róbert Effects of a single intraperitoneal administration of cadmium on femoral bone structure in male rats |
title | Effects of a single intraperitoneal administration of cadmium on femoral bone structure in male rats |
title_full | Effects of a single intraperitoneal administration of cadmium on femoral bone structure in male rats |
title_fullStr | Effects of a single intraperitoneal administration of cadmium on femoral bone structure in male rats |
title_full_unstemmed | Effects of a single intraperitoneal administration of cadmium on femoral bone structure in male rats |
title_short | Effects of a single intraperitoneal administration of cadmium on femoral bone structure in male rats |
title_sort | effects of a single intraperitoneal administration of cadmium on femoral bone structure in male rats |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179732/ https://www.ncbi.nlm.nih.gov/pubmed/21884588 http://dx.doi.org/10.1186/1751-0147-53-49 |
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