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Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts
BACKGROUND: In around 50% of all human cancers the tumor suppressor p53 is mutated. It is generally assumed that in the remaining tumors the wild-type p53 protein is functionally impaired. The two main inhibitors of p53, hMDM2 (MDM2) and hMDMX (MDMX/MDM4) are frequently overexpressed in wild-type p5...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179748/ https://www.ncbi.nlm.nih.gov/pubmed/21910853 http://dx.doi.org/10.1186/1476-4598-10-111 |