Inhibitory effects of the JAK inhibitor CP690,550 on human CD4(+ )T lymphocyte cytokine production

BACKGROUND: The new JAK3 inhibitor, CP690,550, has shown efficacy in the treatment of rheumatoid arthritis. The present study was undertaken to assess the effects of CP690,550 on cytokine production and cellular signaling in human CD4(+ )T cells. RESULTS: CD4(+ )T cells produced IL-2, IL-4, IL-17, I...

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Detalles Bibliográficos
Autores principales: Migita, Kiyoshi, Miyashita, Taiichiro, Izumi, Yasumori, Koga, Tomohiro, Komori, Atsumasa, Maeda, Yumi, Jiuchi, Yuka, Aiba, Yoshihiro, Yamasaki, Satoshi, Kawakami, Atsushi, Nakamura, Minoru, Ishibashi, Hiromi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179939/
https://www.ncbi.nlm.nih.gov/pubmed/21884580
http://dx.doi.org/10.1186/1471-2172-12-51

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