Correlation of MGMT promoter methylation status with gene and protein expression levels in glioblastoma

OBJECTIVES: 1) To correlate the methylation status of the O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter to its gene and protein expression levels in glioblastoma and 2) to determine the most reliable method for using MGMT to predict the response to adjuvant therapy in patients with gliobl...

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Detalles Bibliográficos
Autores principales: Uno, Miyuki, Oba-Shinjo, Sueli Mieko, Camargo, Anamaria Aranha, Moura, Ricardo Pereira, de Aguiar, Paulo Henrique, Cabrera, Hector Navarro, Begnami, Marcos, Rosemberg, Sérgio, Teixeira, Manoel Jacobsen, Marie, Suely Kazue Nagahashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2011
Materias:
Clinical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180167/
https://www.ncbi.nlm.nih.gov/pubmed/22012047
http://dx.doi.org/10.1590/S1807-59322011001000013

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