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Deep resequencing of the voltage-gated potassium channel subunit KCNE3 gene in chronic tinnitus
Membrane-stabilizing drugs have long been used for the treatment of chronic tinnitus, suggesting an underlying disturbance of sensory excitability due to changes in ion conductance. The present study addresses the potassium channel subunit gene KCNE3 as a potential candidate for tinnitus susceptibil...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180252/ https://www.ncbi.nlm.nih.gov/pubmed/21899751 http://dx.doi.org/10.1186/1744-9081-7-39 |
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author | Sand, Philipp G Langguth, Berthold Kleinjung, Tobias |
author_facet | Sand, Philipp G Langguth, Berthold Kleinjung, Tobias |
author_sort | Sand, Philipp G |
collection | PubMed |
description | Membrane-stabilizing drugs have long been used for the treatment of chronic tinnitus, suggesting an underlying disturbance of sensory excitability due to changes in ion conductance. The present study addresses the potassium channel subunit gene KCNE3 as a potential candidate for tinnitus susceptibility. 288 Caucasian outpatients with a diagnosis of chronic tinnitus were systematically screened for mutations in the KCNE3 open reading frame and in the adjacent region by direct sequencing. Allele frequencies were determined for 11 known variants of which two (F66F and R83H) were polymorphic but were not associated with the disorder. No novel variants were identified and only three carriers of R83H were noted. However, owing to a lack of power, our study can neither rule out effects of KCNE3 on the risk for developing chronic tinnitus, nor can it exclude a role in predicting the severity of tinnitus. More extensive investigations are invited, including tests for possible effects of variation in this ion channel protein on the response to treatment. |
format | Online Article Text |
id | pubmed-3180252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31802522011-09-27 Deep resequencing of the voltage-gated potassium channel subunit KCNE3 gene in chronic tinnitus Sand, Philipp G Langguth, Berthold Kleinjung, Tobias Behav Brain Funct Short Paper Membrane-stabilizing drugs have long been used for the treatment of chronic tinnitus, suggesting an underlying disturbance of sensory excitability due to changes in ion conductance. The present study addresses the potassium channel subunit gene KCNE3 as a potential candidate for tinnitus susceptibility. 288 Caucasian outpatients with a diagnosis of chronic tinnitus were systematically screened for mutations in the KCNE3 open reading frame and in the adjacent region by direct sequencing. Allele frequencies were determined for 11 known variants of which two (F66F and R83H) were polymorphic but were not associated with the disorder. No novel variants were identified and only three carriers of R83H were noted. However, owing to a lack of power, our study can neither rule out effects of KCNE3 on the risk for developing chronic tinnitus, nor can it exclude a role in predicting the severity of tinnitus. More extensive investigations are invited, including tests for possible effects of variation in this ion channel protein on the response to treatment. BioMed Central 2011-09-07 /pmc/articles/PMC3180252/ /pubmed/21899751 http://dx.doi.org/10.1186/1744-9081-7-39 Text en Copyright ©2011 Sand et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Paper Sand, Philipp G Langguth, Berthold Kleinjung, Tobias Deep resequencing of the voltage-gated potassium channel subunit KCNE3 gene in chronic tinnitus |
title | Deep resequencing of the voltage-gated potassium channel subunit KCNE3 gene in chronic tinnitus |
title_full | Deep resequencing of the voltage-gated potassium channel subunit KCNE3 gene in chronic tinnitus |
title_fullStr | Deep resequencing of the voltage-gated potassium channel subunit KCNE3 gene in chronic tinnitus |
title_full_unstemmed | Deep resequencing of the voltage-gated potassium channel subunit KCNE3 gene in chronic tinnitus |
title_short | Deep resequencing of the voltage-gated potassium channel subunit KCNE3 gene in chronic tinnitus |
title_sort | deep resequencing of the voltage-gated potassium channel subunit kcne3 gene in chronic tinnitus |
topic | Short Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180252/ https://www.ncbi.nlm.nih.gov/pubmed/21899751 http://dx.doi.org/10.1186/1744-9081-7-39 |
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