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Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice

BACKGROUND AND PURPOSE: Oligodendrocyte (OL) death is important in focal cerebral ischemia. TIMP-3 promotes apoptosis in ischemic neurons by inhibiting proteolysis of TNF-α superfamily of death receptors. Since OLs undergo apoptosis during ischemia, we hypothesized that TIMP-3 contributes to OL deat...

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Detalles Bibliográficos
Autores principales:	Yang, Yi, Jalal, Fakhreya Y, Thompson, Jeffrey F, Walker, Espen J, Candelario-Jalil, Eduardo, Li, Lu, Reichard, Ross R, Ben, Chi, Sang, Qing-Xiang, Cunningham, Lee Anna, Rosenberg, Gary A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180275/ https://www.ncbi.nlm.nih.gov/pubmed/21871134 http://dx.doi.org/10.1186/1742-2094-8-108

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