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The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Induces Tumor Regression in a Genetically Engineered Mouse Model of PIK3CA Wild-Type Colorectal Cancer

PURPOSE: To examine the in vitro and in vivo efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in treatment of PIK3CA wild-type colorectal cancer (CRC). EXPERIMENTAL DESIGN: PIK3CA mutant and wild-type human CRC cell lines were treated in vitro with NVP-BEZ235, and the resulting effects on prolife...

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Detalles Bibliográficos
Autores principales:	Roper, Jatin, Richardson, Michael P., Wang, Wei Vivian, Richard, Larissa Georgeon, Chen, Wei, Coffee, Erin M., Sinnamon, Mark J., Lee, Lydia, Chen, Peng-Chieh, Bronson, Roderick T., Martin, Eric S., Hung, Kenneth E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180374/ https://www.ncbi.nlm.nih.gov/pubmed/21966435 http://dx.doi.org/10.1371/journal.pone.0025132

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