A fiber-modified adenoviral vector interacts with immunoevasion molecules of the B7 family at the surface of murine leukemia cells derived from dormant tumors

Tumor cells can escape the immune system by overexpressing molecules of the B7 family, e.g. B7-H1 (PD-L1 or CD86), which suppresses the anti-tumor T-cell responses through binding to the PD-1 receptor, and similarly for B7.1 (CD80), through binding to CTLA-4. Moreover, direct interactions between B7...

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Detalles Bibliográficos
Autores principales: Grellier, Elodie, Lécolle, Katia, Rogée, Sophie, Couturier, Cyril, D'Halluin, Jean-Claude, Hong, Saw-See, Fender, Pascal, Boulanger, Pierre, Quesnel, Bruno, Colin, Morvane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180432/
https://www.ncbi.nlm.nih.gov/pubmed/21884581
http://dx.doi.org/10.1186/1476-4598-10-105

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