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Morning cortisol is lower in obese individuals with normal glucose tolerance

BACKGROUND: There is no consensus on the role of cortisol in the pathogenesis of obesity and metabolic syndrome (MS). This cross-sectional study aimed to analyze the relationship of morning plasma cortisol and adrenocorticotropic hormone (ACTH) levels with body mass index (BMI) and glucose tolerance...

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Autores principales: Praveen, Edavan P, Sahoo, Jaya Prakash, Kulshreshtha, Bindu, Khurana, Madan L, Gupta, Nandita, Dwivedi, Sada Nand, Kumar, Guresh, Ammini, Ariachery C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180524/
https://www.ncbi.nlm.nih.gov/pubmed/21969806
http://dx.doi.org/10.2147/DMSO.S23915
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author Praveen, Edavan P
Sahoo, Jaya Prakash
Kulshreshtha, Bindu
Khurana, Madan L
Gupta, Nandita
Dwivedi, Sada Nand
Kumar, Guresh
Ammini, Ariachery C
author_facet Praveen, Edavan P
Sahoo, Jaya Prakash
Kulshreshtha, Bindu
Khurana, Madan L
Gupta, Nandita
Dwivedi, Sada Nand
Kumar, Guresh
Ammini, Ariachery C
author_sort Praveen, Edavan P
collection PubMed
description BACKGROUND: There is no consensus on the role of cortisol in the pathogenesis of obesity and metabolic syndrome (MS). This cross-sectional study aimed to analyze the relationship of morning plasma cortisol and adrenocorticotropic hormone (ACTH) levels with body mass index (BMI) and glucose tolerance. SUBJECTS AND METHODS: The sample frame was the “Offspring of individuals with diabetes study” database. A total of 358 offspring of individuals with type 2 diabetes mellitus (T2DM) and 287 individuals without a known family history of T2DM were recruited for the study. Subjects who were ≥10 years of age were selected from the database for analysis. Subjects with T2DM were excluded. All participants underwent a 75 g oral glucose tolerance test (OGTT), and blood samples were collected at 0, 30, 60, and 120 minutes for glucose, insulin and C-peptide. Plasma cortisol, ACTH, and lipid profile were estimated from the fasting sample. RESULTS: Four hundred and ninety-five participants (305 males [62%] and 190 females [38%]) were included in the analysis. ACTH and cortisol levels were higher in normal-weight subjects than in overweight/obese subjects. Both ACTH and cortisol increased as fasting plasma glucose increased. Cortisol levels were significantly lower in offspring of T2DM subjects with MS than in offspring of T2DM subjects without MS. When adjusted for BMI, the significance was marginal. In males, cortisol levels were negatively correlated with early insulin secretion during OGTT (insulinogenic index [0–30]) and positively with waist circumference and serum high-density lipoprotein cholesterol. In females, fasting glucose and systolic blood pressure were significantly and positively correlated. CONCLUSION: Body weight was correlated negatively with morning plasma cortisol and ACTH, whereas fasting glucose was correlated positively.
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spelling pubmed-31805242011-10-03 Morning cortisol is lower in obese individuals with normal glucose tolerance Praveen, Edavan P Sahoo, Jaya Prakash Kulshreshtha, Bindu Khurana, Madan L Gupta, Nandita Dwivedi, Sada Nand Kumar, Guresh Ammini, Ariachery C Diabetes Metab Syndr Obes Original Research BACKGROUND: There is no consensus on the role of cortisol in the pathogenesis of obesity and metabolic syndrome (MS). This cross-sectional study aimed to analyze the relationship of morning plasma cortisol and adrenocorticotropic hormone (ACTH) levels with body mass index (BMI) and glucose tolerance. SUBJECTS AND METHODS: The sample frame was the “Offspring of individuals with diabetes study” database. A total of 358 offspring of individuals with type 2 diabetes mellitus (T2DM) and 287 individuals without a known family history of T2DM were recruited for the study. Subjects who were ≥10 years of age were selected from the database for analysis. Subjects with T2DM were excluded. All participants underwent a 75 g oral glucose tolerance test (OGTT), and blood samples were collected at 0, 30, 60, and 120 minutes for glucose, insulin and C-peptide. Plasma cortisol, ACTH, and lipid profile were estimated from the fasting sample. RESULTS: Four hundred and ninety-five participants (305 males [62%] and 190 females [38%]) were included in the analysis. ACTH and cortisol levels were higher in normal-weight subjects than in overweight/obese subjects. Both ACTH and cortisol increased as fasting plasma glucose increased. Cortisol levels were significantly lower in offspring of T2DM subjects with MS than in offspring of T2DM subjects without MS. When adjusted for BMI, the significance was marginal. In males, cortisol levels were negatively correlated with early insulin secretion during OGTT (insulinogenic index [0–30]) and positively with waist circumference and serum high-density lipoprotein cholesterol. In females, fasting glucose and systolic blood pressure were significantly and positively correlated. CONCLUSION: Body weight was correlated negatively with morning plasma cortisol and ACTH, whereas fasting glucose was correlated positively. Dove Medical Press 2011-09-07 /pmc/articles/PMC3180524/ /pubmed/21969806 http://dx.doi.org/10.2147/DMSO.S23915 Text en © 2011 Praveen et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Praveen, Edavan P
Sahoo, Jaya Prakash
Kulshreshtha, Bindu
Khurana, Madan L
Gupta, Nandita
Dwivedi, Sada Nand
Kumar, Guresh
Ammini, Ariachery C
Morning cortisol is lower in obese individuals with normal glucose tolerance
title Morning cortisol is lower in obese individuals with normal glucose tolerance
title_full Morning cortisol is lower in obese individuals with normal glucose tolerance
title_fullStr Morning cortisol is lower in obese individuals with normal glucose tolerance
title_full_unstemmed Morning cortisol is lower in obese individuals with normal glucose tolerance
title_short Morning cortisol is lower in obese individuals with normal glucose tolerance
title_sort morning cortisol is lower in obese individuals with normal glucose tolerance
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180524/
https://www.ncbi.nlm.nih.gov/pubmed/21969806
http://dx.doi.org/10.2147/DMSO.S23915
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