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Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: I. Co-Regulation by Activity
Besides the massive plasticity at the level of synapses, we find in the hippocampus of adult mice and rats two systems with very strong macroscopic structural plasticity: adult neurogenesis, that is the lifelong generation of new granule cells, and dynamic changes in the mossy fibers linking the den...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180604/ https://www.ncbi.nlm.nih.gov/pubmed/21991243 http://dx.doi.org/10.3389/fnins.2011.00107 |
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author | Römer, Benedikt Krebs, Julia Overall, Rupert W. Fabel, Klaus Babu, Harish Overstreet-Wadiche, Linda Brandt, Moritz D. Williams, Robert W. Jessberger, Sebastian Kempermann, Gerd |
author_facet | Römer, Benedikt Krebs, Julia Overall, Rupert W. Fabel, Klaus Babu, Harish Overstreet-Wadiche, Linda Brandt, Moritz D. Williams, Robert W. Jessberger, Sebastian Kempermann, Gerd |
author_sort | Römer, Benedikt |
collection | PubMed |
description | Besides the massive plasticity at the level of synapses, we find in the hippocampus of adult mice and rats two systems with very strong macroscopic structural plasticity: adult neurogenesis, that is the lifelong generation of new granule cells, and dynamic changes in the mossy fibers linking the dentate gyrus to area CA3. In particular the anatomy of the infrapyramidal mossy fiber tract (IMF) changes in response to a variety of extrinsic and intrinsic stimuli. Because mossy fibers are the axons of granule cells, the question arises whether these two types of plasticity are linked. Using immunohistochemistry for markers associated with axonal growth and pro-opiomelanocortin (POMC)–GFP mice to visualize the post-mitotic maturation phase of adult hippocampal neurogenesis, we found that newly generated mossy fibers preferentially but not exclusively contribute to the IMF. The neurogenic stimulus of an enriched environment increased the volume of the IMF. In addition, the IMF grew with a time course consistent with axonal outgrowth from the newborn neurons after the induction of neurogenic seizures using kainate. These results indicate that two aspects of plasticity in the adult hippocampus, mossy fiber size and neurogenesis, are related and may share underlying mechanisms. In a second part of this study, published separately (Krebs et al., 2011) we have addressed the question of whether there is a shared genetics underlying both traits. |
format | Online Article Text |
id | pubmed-3180604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31806042011-10-11 Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: I. Co-Regulation by Activity Römer, Benedikt Krebs, Julia Overall, Rupert W. Fabel, Klaus Babu, Harish Overstreet-Wadiche, Linda Brandt, Moritz D. Williams, Robert W. Jessberger, Sebastian Kempermann, Gerd Front Neurosci Neuroscience Besides the massive plasticity at the level of synapses, we find in the hippocampus of adult mice and rats two systems with very strong macroscopic structural plasticity: adult neurogenesis, that is the lifelong generation of new granule cells, and dynamic changes in the mossy fibers linking the dentate gyrus to area CA3. In particular the anatomy of the infrapyramidal mossy fiber tract (IMF) changes in response to a variety of extrinsic and intrinsic stimuli. Because mossy fibers are the axons of granule cells, the question arises whether these two types of plasticity are linked. Using immunohistochemistry for markers associated with axonal growth and pro-opiomelanocortin (POMC)–GFP mice to visualize the post-mitotic maturation phase of adult hippocampal neurogenesis, we found that newly generated mossy fibers preferentially but not exclusively contribute to the IMF. The neurogenic stimulus of an enriched environment increased the volume of the IMF. In addition, the IMF grew with a time course consistent with axonal outgrowth from the newborn neurons after the induction of neurogenic seizures using kainate. These results indicate that two aspects of plasticity in the adult hippocampus, mossy fiber size and neurogenesis, are related and may share underlying mechanisms. In a second part of this study, published separately (Krebs et al., 2011) we have addressed the question of whether there is a shared genetics underlying both traits. Frontiers Research Foundation 2011-09-27 /pmc/articles/PMC3180604/ /pubmed/21991243 http://dx.doi.org/10.3389/fnins.2011.00107 Text en Copyright © 2011 Römer, Krebs, Overall, Fabel, Babu, Overstreet-Wadiche, Brandt, Williams, Jessberger and Kempermann. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. |
spellingShingle | Neuroscience Römer, Benedikt Krebs, Julia Overall, Rupert W. Fabel, Klaus Babu, Harish Overstreet-Wadiche, Linda Brandt, Moritz D. Williams, Robert W. Jessberger, Sebastian Kempermann, Gerd Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: I. Co-Regulation by Activity |
title | Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: I. Co-Regulation by Activity |
title_full | Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: I. Co-Regulation by Activity |
title_fullStr | Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: I. Co-Regulation by Activity |
title_full_unstemmed | Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: I. Co-Regulation by Activity |
title_short | Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: I. Co-Regulation by Activity |
title_sort | adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: i. co-regulation by activity |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180604/ https://www.ncbi.nlm.nih.gov/pubmed/21991243 http://dx.doi.org/10.3389/fnins.2011.00107 |
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