A genistein derivative, ITB-301, induces microtubule depolymerization and mitotic arrest in multidrug-resistant ovarian cancer

PURPOSE: To investigate the mechanistic basis of the anti-tumor effect of the compound ITB-301. METHODS: Chemical modifications of genistein have been introduced to improve its solubility and efficacy. The anti-tumor effects were tested in ovarian cancer cells using proliferation assays, cell cycle...

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Detalles Bibliográficos
Autores principales: Ahmed, Ahmed Ashour, Goldsmith, Juliet, Fokt, Izabela, Le, Xiao-Feng, Krzysko, Krystiana A., Lesyng, Bogdan, Bast, Robert C., Priebe, Waldemar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180612/
https://www.ncbi.nlm.nih.gov/pubmed/21340606
http://dx.doi.org/10.1007/s00280-011-1575-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180612/
https://www.ncbi.nlm.nih.gov/pubmed/21340606
http://dx.doi.org/10.1007/s00280-011-1575-2

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