Cargando…

A genistein derivative, ITB-301, induces microtubule depolymerization and mitotic arrest in multidrug-resistant ovarian cancer

PURPOSE: To investigate the mechanistic basis of the anti-tumor effect of the compound ITB-301. METHODS: Chemical modifications of genistein have been introduced to improve its solubility and efficacy. The anti-tumor effects were tested in ovarian cancer cells using proliferation assays, cell cycle...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahmed, Ahmed Ashour, Goldsmith, Juliet, Fokt, Izabela, Le, Xiao-Feng, Krzysko, Krystiana A., Lesyng, Bogdan, Bast, Robert C., Priebe, Waldemar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2011
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180612/ https://www.ncbi.nlm.nih.gov/pubmed/21340606 http://dx.doi.org/10.1007/s00280-011-1575-2

Ejemplares similares

Exploring Covalent Docking Mechanisms of Boron-Based Inhibitors to Class A, C and D β-Lactamases Using Time-dependent Hybrid QM/MM Simulations
por: Charzewski, Łukasz, et al.
Publicado: (2021)

Structural characterisation of inhibitory and non-inhibitory MMP-9–TIMP-1 complexes and implications for regulatory mechanisms of MMP-9
por: Charzewski, Łukasz, et al.
Publicado: (2021)

Reorganization of paclitaxel-stabilized microtubule arrays at mitotic entry: roles of depolymerizing kinesins and severing proteins
por: Leung, Jessica C., et al.
Publicado: (2019)

Dynamics of microtubule depolymerization in monocytes
Publicado: (1986)

Picropodophyllin causes mitotic arrest and catastrophe by depolymerizing microtubules via Insulin-like growth factor-1 receptor-independent mechanism
por: Waraky, Ahmed, et al.
Publicado: (2014)

Drug Conjugates for Targeting Eph Receptors in Glioblastoma
por: Sharma, Puja, et al.
Publicado: (2020)

Microtubule Depolymerization Potentiates Alpha-Synuclein Oligomerization
por: Esteves, A. Raquel, et al.
Publicado: (2010)

Spatial variation of microtubule depolymerization in large asters
por: Ishihara, Keisuke, et al.
Publicado: (2021)

Microtubule-binding protein FOR20 promotes microtubule depolymerization and cell migration
por: Feng, Sijie, et al.
Publicado: (2017)

Microtubule depolymerization promotes particle and chromosome movement in vitro
Publicado: (1991)

Temperature dependence of anaphase chromosome velocity and microtubule depolymerization
Publicado: (1975)

Determinants of cytoplasmic microtubule depolymerization during ciliogenesis in Chlamydomonas
por: Dougherty, Larissa L, et al.
Publicado: (2023)

Microtubule depolymerization contributes to spontaneous neurotransmitter release in vitro
por: Velasco, Cecilia D., et al.
Publicado: (2023)

A synthetic ancestral kinesin-13 depolymerizes microtubules faster than any natural depolymerizing kinesin
por: Belsham, Hannah R., et al.
Publicado: (2022)

The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation
por: Miyamoto, Tatsuo, et al.
Publicado: (2015)

Effect of structural modification at the 4, 3′, and 2′ positions of doxorubicin on topoisomerase II poisoning, apoptosis, and cytotoxicity in human melanoma cells
por: Gruber, Beata M., et al.
Publicado: (2007)

Endoscopic Gluteus Medius Repair With an ITB-Sparing Versus ITB-Splitting Approach: A Systematic Review and Meta-analysis
por: Parker, Emily A., et al.
Publicado: (2020)

Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance
por: Manzoor, Safia, et al.
Publicado: (2018)

A Molecular Dynamics Study of Vasoactive Intestinal Peptide Receptor 1 and the Basis of Its Therapeutic Antagonism
por: Latek, Dorota, et al.
Publicado: (2019)

A kinesin-13 mutant catalytically depolymerizes microtubules in ADP
por: Wagenbach, Michael, et al.
Publicado: (2008)

Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin
por: Ng, Dominic Chi Hiung, et al.
Publicado: (2006)

A new role for motor proteins as couplers to depolymerizing microtubules
Publicado: (1995)

Microinjection of Ca++-calmodulin causes a localized depolymerization of microtubules
Publicado: (1983)

Microtubule Depolymerization by Kinase Inhibitors: Unexpected Findings of Dual Inhibitors
por: Tanabe, Kenji
Publicado: (2017)

Molecular basis of resistance to the microtubule-depolymerizing antitumor compound plocabulin
por: Pantazopoulou, Areti, et al.
Publicado: (2018)

Enhanced tumor cell killing by ultrasound after microtubule depolymerization
por: Singh, Aditi, et al.
Publicado: (2021)

Determinants of cytoplasmic microtubule depolymerization during ciliogenesis in Chlamydomonas reinhardtii
por: Dougherty, Larissa L, et al.
Publicado: (2023)

Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301
por: Chopra, Avijeet, et al.
Publicado: (2016)

HIV-1 Rev Depolymerizes Microtubules to Form Stable Bilayered Rings
por: Watts, Norman R., et al.
Publicado: (2000)

Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s
por: Benoit, Matthieu P.M.H., et al.
Publicado: (2018)

Katanin catalyzes microtubule depolymerization independently of tubulin C‐terminal tails
por: Belonogov, Liudmila, et al.
Publicado: (2019)

CRK41 Modulates Microtubule Depolymerization in Response to Salt Stress in Arabidopsis
por: Zhou, Sa, et al.
Publicado: (2023)

Fast Wave Current Drive in JET ITB-Plasmas
por: Hellsten, T, et al.
Publicado: (2003)

Molecular modelling of mitofusin 2 for a prediction for Charcot-Marie-Tooth 2A clinical severity
por: Beręsewicz, Małgorzata, et al.
Publicado: (2018)

Author Correction: Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance
por: Manzoor, Safia, et al.
Publicado: (2018)

Bis-anthracycline WP760 abrogates melanoma cell growth by transcription inhibition, p53 activation and IGF1R downregulation
por: Olbryt, Magdalena, et al.
Publicado: (2017)

The Antiviral Effects of 2-Deoxy-D-glucose (2-DG), a Dual D-Glucose and D-Mannose Mimetic, against SARS-CoV-2 and Other Highly Pathogenic Viruses
por: Pająk, Beata, et al.
Publicado: (2022)

Depolymerization of microtubules increases the motional freedom of molecular probes in cellular plasma membranes
Publicado: (1985)

Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B
Publicado: (1995)

Pressure-induced depolymerization of spindle microtubules. I. Changes in birefringence and spindle length
Publicado: (1975)

Cannot write session to /tmp/vufind_sessions/sess_nm06dfabv65eam738seo86v29r