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Diagnosis/Classification Criteria for Behcet's Disease

Historical Background. The ISG criteria for Behcet's, created in 1990, have excellent specificity, but lack sensitivity. The International Criteria for Behcet's Disease (ICBD) was created in 2006, as replacement to ISG. The aim of this study was to compare their performance. ISG and ICBD C...

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Autor principal: Davatchi, Fereydoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180812/
https://www.ncbi.nlm.nih.gov/pubmed/21961081
http://dx.doi.org/10.1155/2012/607921
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author Davatchi, Fereydoun
author_facet Davatchi, Fereydoun
author_sort Davatchi, Fereydoun
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description Historical Background. The ISG criteria for Behcet's, created in 1990, have excellent specificity, but lack sensitivity. The International Criteria for Behcet's Disease (ICBD) was created in 2006, as replacement to ISG. The aim of this study was to compare their performance. ISG and ICBD Criteria. For ISG oral aphthosis is mandatory. The presence of any two of the following (genital aphthosis, skin lesions, eye lesions, and positive pathergy test) will diagnose/classify the patient as BD. For ICBD, vascular lesions were added, while oral aphthosis is no more mandatory. Getting 3 or more points diagnose/classify the patient as BD (genital aphthosis 2 points, eye lesions 2 points, and the remaining each one point). Performance and Comparison of ISG and ICBD. Their sensitivity, specificity, and accuracy (percent agreement), were tested in three independent cohort of patients from Far-East (China), Middle-East (Iran), and Europe (Germany). The sensitivity for ISG was respectively 65.4%, 78.1%, 83.7% and for ICBD 87%, 98.2%, and 96.5%. The specificity for ISG was 99.2%, 98.8%, 89.5% and for ICBD 94.1%, 95.6%, and 73.7%. The accuracy for ISG was 74.2%, 85.5%, 85.5% and for ICBD 88.9%, 97.3%, and 89.5%. Conclusion. ICBD has better sensitivity, and accuracy than ISG.
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spelling pubmed-31808122011-09-29 Diagnosis/Classification Criteria for Behcet's Disease Davatchi, Fereydoun Patholog Res Int Review Article Historical Background. The ISG criteria for Behcet's, created in 1990, have excellent specificity, but lack sensitivity. The International Criteria for Behcet's Disease (ICBD) was created in 2006, as replacement to ISG. The aim of this study was to compare their performance. ISG and ICBD Criteria. For ISG oral aphthosis is mandatory. The presence of any two of the following (genital aphthosis, skin lesions, eye lesions, and positive pathergy test) will diagnose/classify the patient as BD. For ICBD, vascular lesions were added, while oral aphthosis is no more mandatory. Getting 3 or more points diagnose/classify the patient as BD (genital aphthosis 2 points, eye lesions 2 points, and the remaining each one point). Performance and Comparison of ISG and ICBD. Their sensitivity, specificity, and accuracy (percent agreement), were tested in three independent cohort of patients from Far-East (China), Middle-East (Iran), and Europe (Germany). The sensitivity for ISG was respectively 65.4%, 78.1%, 83.7% and for ICBD 87%, 98.2%, and 96.5%. The specificity for ISG was 99.2%, 98.8%, 89.5% and for ICBD 94.1%, 95.6%, and 73.7%. The accuracy for ISG was 74.2%, 85.5%, 85.5% and for ICBD 88.9%, 97.3%, and 89.5%. Conclusion. ICBD has better sensitivity, and accuracy than ISG. Hindawi Publishing Corporation 2012 2011-09-27 /pmc/articles/PMC3180812/ /pubmed/21961081 http://dx.doi.org/10.1155/2012/607921 Text en Copyright © 2012 Fereydoun Davatchi. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Davatchi, Fereydoun
Diagnosis/Classification Criteria for Behcet's Disease
title Diagnosis/Classification Criteria for Behcet's Disease
title_full Diagnosis/Classification Criteria for Behcet's Disease
title_fullStr Diagnosis/Classification Criteria for Behcet's Disease
title_full_unstemmed Diagnosis/Classification Criteria for Behcet's Disease
title_short Diagnosis/Classification Criteria for Behcet's Disease
title_sort diagnosis/classification criteria for behcet's disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180812/
https://www.ncbi.nlm.nih.gov/pubmed/21961081
http://dx.doi.org/10.1155/2012/607921
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