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Synaptic Wnt signaling—a contributor to major psychiatric disorders?

Wnt signaling is a key pathway that helps organize development of the nervous system. It influences cell proliferation, cell fate, and cell migration in the developing nervous system, as well as axon guidance, dendrite development, and synapse formation. Given this wide range of roles, dysregulation...

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Detalles Bibliográficos
Autores principales: Okerlund, Nathan D., Cheyette, Benjamin N. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180925/
https://www.ncbi.nlm.nih.gov/pubmed/21533542
http://dx.doi.org/10.1007/s11689-011-9083-6
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author Okerlund, Nathan D.
Cheyette, Benjamin N. R.
author_facet Okerlund, Nathan D.
Cheyette, Benjamin N. R.
author_sort Okerlund, Nathan D.
collection PubMed
description Wnt signaling is a key pathway that helps organize development of the nervous system. It influences cell proliferation, cell fate, and cell migration in the developing nervous system, as well as axon guidance, dendrite development, and synapse formation. Given this wide range of roles, dysregulation of Wnt signaling could have any number of deleterious effects on neural development and thereby contribute in many different ways to the pathogenesis of neurodevelopmental disorders. Some major psychiatric disorders, including schizophrenia, bipolar disorder, and autism spectrum disorders, are coming to be understood as subtle dysregulations of nervous system development, particularly of synapse formation and maintenance. This review will therefore touch on the importance of Wnt signaling to neurodevelopment generally, while focusing on accumulating evidence for a synaptic role of Wnt signaling. These observations will be discussed in the context of current understanding of the neurodevelopmental bases of major psychiatric diseases, spotlighting schizophrenia, bipolar disorder, and autism spectrum disorder. In short, this review will focus on the potential role of synapse formation and maintenance in major psychiatric disorders and summarize evidence that defective Wnt signaling could contribute to their pathogenesis via effects on these late neural differentiation processes.
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spelling pubmed-31809252011-09-27 Synaptic Wnt signaling—a contributor to major psychiatric disorders? Okerlund, Nathan D. Cheyette, Benjamin N. R. J Neurodev Disord Article Wnt signaling is a key pathway that helps organize development of the nervous system. It influences cell proliferation, cell fate, and cell migration in the developing nervous system, as well as axon guidance, dendrite development, and synapse formation. Given this wide range of roles, dysregulation of Wnt signaling could have any number of deleterious effects on neural development and thereby contribute in many different ways to the pathogenesis of neurodevelopmental disorders. Some major psychiatric disorders, including schizophrenia, bipolar disorder, and autism spectrum disorders, are coming to be understood as subtle dysregulations of nervous system development, particularly of synapse formation and maintenance. This review will therefore touch on the importance of Wnt signaling to neurodevelopment generally, while focusing on accumulating evidence for a synaptic role of Wnt signaling. These observations will be discussed in the context of current understanding of the neurodevelopmental bases of major psychiatric diseases, spotlighting schizophrenia, bipolar disorder, and autism spectrum disorder. In short, this review will focus on the potential role of synapse formation and maintenance in major psychiatric disorders and summarize evidence that defective Wnt signaling could contribute to their pathogenesis via effects on these late neural differentiation processes. Springer US 2011-04-28 2011-06 /pmc/articles/PMC3180925/ /pubmed/21533542 http://dx.doi.org/10.1007/s11689-011-9083-6 Text en © Springer Science+Business Media, LLC 2011
spellingShingle Article
Okerlund, Nathan D.
Cheyette, Benjamin N. R.
Synaptic Wnt signaling—a contributor to major psychiatric disorders?
title Synaptic Wnt signaling—a contributor to major psychiatric disorders?
title_full Synaptic Wnt signaling—a contributor to major psychiatric disorders?
title_fullStr Synaptic Wnt signaling—a contributor to major psychiatric disorders?
title_full_unstemmed Synaptic Wnt signaling—a contributor to major psychiatric disorders?
title_short Synaptic Wnt signaling—a contributor to major psychiatric disorders?
title_sort synaptic wnt signaling—a contributor to major psychiatric disorders?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180925/
https://www.ncbi.nlm.nih.gov/pubmed/21533542
http://dx.doi.org/10.1007/s11689-011-9083-6
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