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Fc γ R IIB gene polymorphisms in Indian systemic lupus erythematosus (SLE) patients

BACKGROUND & OBJECTIVES: Receptors for the Fc fragment of immunoglobulin G (Fc γ Rs) represent the link between humoral and cellular immune responses. Polymorphisms in Fc γ Rs have been identified as genetic factors influencing susceptibility to various autoimmune diseases. This study was aimed...

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Autores principales: Pradhan, Vandana, Patwardhan, Manisha, Nadkarni, Anita, Ghosh, Kanjaksha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181018/
https://www.ncbi.nlm.nih.gov/pubmed/21911970
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author Pradhan, Vandana
Patwardhan, Manisha
Nadkarni, Anita
Ghosh, Kanjaksha
author_facet Pradhan, Vandana
Patwardhan, Manisha
Nadkarni, Anita
Ghosh, Kanjaksha
author_sort Pradhan, Vandana
collection PubMed
description BACKGROUND & OBJECTIVES: Receptors for the Fc fragment of immunoglobulin G (Fc γ Rs) represent the link between humoral and cellular immune responses. Polymorphisms in Fc γ Rs have been identified as genetic factors influencing susceptibility to various autoimmune diseases. This study was aimed to identify Fc γ R IIB genotypes in Indian systemic lupus erythematosus (SLE) patients and to correlate these with clinical presentation and autoantibody profile. METHODS: Eighty consecutive clinically diagnosed SLE patients were included. SLE patients were classified according to the American College of Rheumatology (ACR) criteria. Disease activity was assessed by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). PCR-RFLP method was used to detect Fc γ R IIB polymorphism. RESULTS: Of the 80 SLE patients, 53 were LN and 27 were SLE without nephritis. The mean SLEDAI score at evaluation was 6.5 ± 5.8. Among SLE patients Fc γ R IIB genotype frequency was 61.2 per cent for Ile/Thr, 20.0 per cent for Thr/Thr and 18.8 per cent for Ile/Ile as compared to 65, 12.5 and 22.5 per cent respectively among normal population. There was no significant difference for Fc γ R IIB genotypes between SLE and normals. The allele frequency for Thr allele in SLE patients was slightly higher (0.51) than in normals (0.45). Thr allele frequency in LN patients was slightly higher (0.53) than in SLE patients without nephritis (0.49). Though a higher percentages of symptoms like renal manifestations (81.3%), arthritis (62.5%) and oral ulcer (56.3%) were noted in patients with Thr/Thr genotypes, no significant difference was noted when these patients were compared with Ile/Ile and Ile/Thr genotypes. INTERPRETATION & CONCLUSIONS: The findings of this study indicate towards an involvement of Thr allele with SLE disease severity and clinical presentation in Indian SLE patients. Future study on a large sample is needed to support this finding to understand the association of Fc γ R IIB 232Thr/Thr genotype as a susceptibility factor in SLE.
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spelling pubmed-31810182011-10-04 Fc γ R IIB gene polymorphisms in Indian systemic lupus erythematosus (SLE) patients Pradhan, Vandana Patwardhan, Manisha Nadkarni, Anita Ghosh, Kanjaksha Indian J Med Res Original Article BACKGROUND & OBJECTIVES: Receptors for the Fc fragment of immunoglobulin G (Fc γ Rs) represent the link between humoral and cellular immune responses. Polymorphisms in Fc γ Rs have been identified as genetic factors influencing susceptibility to various autoimmune diseases. This study was aimed to identify Fc γ R IIB genotypes in Indian systemic lupus erythematosus (SLE) patients and to correlate these with clinical presentation and autoantibody profile. METHODS: Eighty consecutive clinically diagnosed SLE patients were included. SLE patients were classified according to the American College of Rheumatology (ACR) criteria. Disease activity was assessed by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). PCR-RFLP method was used to detect Fc γ R IIB polymorphism. RESULTS: Of the 80 SLE patients, 53 were LN and 27 were SLE without nephritis. The mean SLEDAI score at evaluation was 6.5 ± 5.8. Among SLE patients Fc γ R IIB genotype frequency was 61.2 per cent for Ile/Thr, 20.0 per cent for Thr/Thr and 18.8 per cent for Ile/Ile as compared to 65, 12.5 and 22.5 per cent respectively among normal population. There was no significant difference for Fc γ R IIB genotypes between SLE and normals. The allele frequency for Thr allele in SLE patients was slightly higher (0.51) than in normals (0.45). Thr allele frequency in LN patients was slightly higher (0.53) than in SLE patients without nephritis (0.49). Though a higher percentages of symptoms like renal manifestations (81.3%), arthritis (62.5%) and oral ulcer (56.3%) were noted in patients with Thr/Thr genotypes, no significant difference was noted when these patients were compared with Ile/Ile and Ile/Thr genotypes. INTERPRETATION & CONCLUSIONS: The findings of this study indicate towards an involvement of Thr allele with SLE disease severity and clinical presentation in Indian SLE patients. Future study on a large sample is needed to support this finding to understand the association of Fc γ R IIB 232Thr/Thr genotype as a susceptibility factor in SLE. Medknow Publications 2011-08 /pmc/articles/PMC3181018/ /pubmed/21911970 Text en Copyright: © The Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Pradhan, Vandana
Patwardhan, Manisha
Nadkarni, Anita
Ghosh, Kanjaksha
Fc γ R IIB gene polymorphisms in Indian systemic lupus erythematosus (SLE) patients
title Fc γ R IIB gene polymorphisms in Indian systemic lupus erythematosus (SLE) patients
title_full Fc γ R IIB gene polymorphisms in Indian systemic lupus erythematosus (SLE) patients
title_fullStr Fc γ R IIB gene polymorphisms in Indian systemic lupus erythematosus (SLE) patients
title_full_unstemmed Fc γ R IIB gene polymorphisms in Indian systemic lupus erythematosus (SLE) patients
title_short Fc γ R IIB gene polymorphisms in Indian systemic lupus erythematosus (SLE) patients
title_sort fc γ r iib gene polymorphisms in indian systemic lupus erythematosus (sle) patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181018/
https://www.ncbi.nlm.nih.gov/pubmed/21911970
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