Effects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon

BACKGROUND: The ABC phenomenon is described as a syndrome of accelerated clearance of polyethylene glycol (PEG)-modified liposomes from the bloodstream when repeatedly injected, with their increased accumulation in the liver and spleen. METHODS: To clarify this immune response phenomenon, we evaluat...

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Detalles Bibliográficos
Autores principales: Chen, Daquan, Liu, Wanhui, Shen, Yan, Mu, Hongjie, Zhang, Yanchun, Liang, Rongcai, Wang, Aiping, Sun, Kaoxiang, Fu, Fenghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181064/
https://www.ncbi.nlm.nih.gov/pubmed/21976980
http://dx.doi.org/10.2147/IJN.S24344

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