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Solvent effects on structural and thermochemical properties of p53 tumor-suppressor gene: a molecular modeling approach in drug design

The p53 tumor-suppressor protein is a cellular phosphoprotein and a negative regulator of cell growth. Most p53 mutations occur in exons 5–8 within the DNA-binding domain. Therefore, p53 can potentially be targeted with novel drugs designed to bind to a mutation and restore its stability or wild-typ...

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Detalles Bibliográficos
Autores principales:	Irani, Shiva, Atyabi, Seyed Mohammad, Mivehchi, Houri, Siadat, Seyed Davar, Aghasadeghi, Mohammad Reza, Farhangi, Ali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2011
Materias:	Perspectives
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181065/ https://www.ncbi.nlm.nih.gov/pubmed/21976981 http://dx.doi.org/10.2147/IJN.S22391

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