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Identification of a Variable Number of Tandem Repeats Polymorphism and Characterization of LEF-1 Response Elements in the Promoter of the IDO1 Gene

BACKGROUND: Indoleamine 2,3-dioxygenase (IDO) catalyzes the first and rate-limiting step of the kynurenine pathway that is an important component of immunomodulatory and neuromodulatory processes. The IDO1 gene is highly inducible by IFN-γ and TNF-α through interaction with cis-acting regulatory ele...

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Detalles Bibliográficos
Autores principales:	Soichot, Marion, Hennart, Benjamin, Al Saabi, Alaa, Leloire, Audrey, Froguel, Philippe, Levy-Marchal, Claire, Poulain-Godefroy, Odile, Allorge, Delphine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181322/ https://www.ncbi.nlm.nih.gov/pubmed/21980470 http://dx.doi.org/10.1371/journal.pone.0025470

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