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The Persistent Circulation of Enterovirus 71 in People's Republic of China: Causing Emerging Nationwide Epidemics Since 2008

Emerging epidemics of hand-foot-and-mouth disease (HFMD) associated with enterovirus 71 (EV71) has become a serious concern in mainland China. It caused 126 and 353 fatalities in 2008 and 2009, respectively. The epidemiologic and pathogenic data of the outbreak collected from national laboratory net...

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Autores principales: Tan, Xiaojuan, Huang, Xueyong, Zhu, Shuangli, Chen, Hui, Yu, Qiuli, Wang, Haiyan, Huo, Xixiang, Zhou, Jianhui, Wu, Yan, Yan, Dongmei, Zhang, Yong, Wang, Dongyan, Cui, Aili, An, Hongqiu, Xu, Wenbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181342/
https://www.ncbi.nlm.nih.gov/pubmed/21980521
http://dx.doi.org/10.1371/journal.pone.0025662
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author Tan, Xiaojuan
Huang, Xueyong
Zhu, Shuangli
Chen, Hui
Yu, Qiuli
Wang, Haiyan
Huo, Xixiang
Zhou, Jianhui
Wu, Yan
Yan, Dongmei
Zhang, Yong
Wang, Dongyan
Cui, Aili
An, Hongqiu
Xu, Wenbo
author_facet Tan, Xiaojuan
Huang, Xueyong
Zhu, Shuangli
Chen, Hui
Yu, Qiuli
Wang, Haiyan
Huo, Xixiang
Zhou, Jianhui
Wu, Yan
Yan, Dongmei
Zhang, Yong
Wang, Dongyan
Cui, Aili
An, Hongqiu
Xu, Wenbo
author_sort Tan, Xiaojuan
collection PubMed
description Emerging epidemics of hand-foot-and-mouth disease (HFMD) associated with enterovirus 71 (EV71) has become a serious concern in mainland China. It caused 126 and 353 fatalities in 2008 and 2009, respectively. The epidemiologic and pathogenic data of the outbreak collected from national laboratory network and notifiable disease surveillance system. To understand the virological evolution of this emerging outbreak, 326 VP1 gene sequences of EV71 detected in China from 1987 to 2009 were collected for genetic analyses. Evidence from both traditional and molecular epidemiology confirmed that the recent HFMD outbreak was an emerging one caused by EV71 of subgenotype C4. This emerging HFMD outbreak is associated with EV71 of subgenotype C4, circulating persistently in mainland China since 1998, but not attributed to the importation of new genotype. Originating from 1992, subgenotype C4 has been the predominant genotype since 1998 in mainland China, with an evolutionary rate of 4.6∼4.8×10(−3) nucleotide substitutions/site/year. The phylogenetic analysis revealed that the majority of the virus during this epidemic was the most recent descendant of subgenotype C4 (clade C4a). It suggests that the evolution might be one of the potential reasons for this native virus to cause the emerging outbreak in China. However, strong negative selective pressure on VP1 protein of EV71 suggested that immune escape might not be the evolving strategy of EV71, predicting a light future for vaccine development. Nonetheless, long-term antigenic and genetic surveillance is still necessary for further understanding.
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spelling pubmed-31813422011-10-06 The Persistent Circulation of Enterovirus 71 in People's Republic of China: Causing Emerging Nationwide Epidemics Since 2008 Tan, Xiaojuan Huang, Xueyong Zhu, Shuangli Chen, Hui Yu, Qiuli Wang, Haiyan Huo, Xixiang Zhou, Jianhui Wu, Yan Yan, Dongmei Zhang, Yong Wang, Dongyan Cui, Aili An, Hongqiu Xu, Wenbo PLoS One Research Article Emerging epidemics of hand-foot-and-mouth disease (HFMD) associated with enterovirus 71 (EV71) has become a serious concern in mainland China. It caused 126 and 353 fatalities in 2008 and 2009, respectively. The epidemiologic and pathogenic data of the outbreak collected from national laboratory network and notifiable disease surveillance system. To understand the virological evolution of this emerging outbreak, 326 VP1 gene sequences of EV71 detected in China from 1987 to 2009 were collected for genetic analyses. Evidence from both traditional and molecular epidemiology confirmed that the recent HFMD outbreak was an emerging one caused by EV71 of subgenotype C4. This emerging HFMD outbreak is associated with EV71 of subgenotype C4, circulating persistently in mainland China since 1998, but not attributed to the importation of new genotype. Originating from 1992, subgenotype C4 has been the predominant genotype since 1998 in mainland China, with an evolutionary rate of 4.6∼4.8×10(−3) nucleotide substitutions/site/year. The phylogenetic analysis revealed that the majority of the virus during this epidemic was the most recent descendant of subgenotype C4 (clade C4a). It suggests that the evolution might be one of the potential reasons for this native virus to cause the emerging outbreak in China. However, strong negative selective pressure on VP1 protein of EV71 suggested that immune escape might not be the evolving strategy of EV71, predicting a light future for vaccine development. Nonetheless, long-term antigenic and genetic surveillance is still necessary for further understanding. Public Library of Science 2011-09-28 /pmc/articles/PMC3181342/ /pubmed/21980521 http://dx.doi.org/10.1371/journal.pone.0025662 Text en Tan et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Tan, Xiaojuan
Huang, Xueyong
Zhu, Shuangli
Chen, Hui
Yu, Qiuli
Wang, Haiyan
Huo, Xixiang
Zhou, Jianhui
Wu, Yan
Yan, Dongmei
Zhang, Yong
Wang, Dongyan
Cui, Aili
An, Hongqiu
Xu, Wenbo
The Persistent Circulation of Enterovirus 71 in People's Republic of China: Causing Emerging Nationwide Epidemics Since 2008
title The Persistent Circulation of Enterovirus 71 in People's Republic of China: Causing Emerging Nationwide Epidemics Since 2008
title_full The Persistent Circulation of Enterovirus 71 in People's Republic of China: Causing Emerging Nationwide Epidemics Since 2008
title_fullStr The Persistent Circulation of Enterovirus 71 in People's Republic of China: Causing Emerging Nationwide Epidemics Since 2008
title_full_unstemmed The Persistent Circulation of Enterovirus 71 in People's Republic of China: Causing Emerging Nationwide Epidemics Since 2008
title_short The Persistent Circulation of Enterovirus 71 in People's Republic of China: Causing Emerging Nationwide Epidemics Since 2008
title_sort persistent circulation of enterovirus 71 in people's republic of china: causing emerging nationwide epidemics since 2008
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181342/
https://www.ncbi.nlm.nih.gov/pubmed/21980521
http://dx.doi.org/10.1371/journal.pone.0025662
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