Novel roles for hERG K(+) channels in cell proliferation and apoptosis

The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular arrhythmias in humans. hERG K(+) channels are a...

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Detalles Bibliográficos
Autores principales: Jehle, J, Schweizer, P A, Katus, H A, Thomas, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181422/
https://www.ncbi.nlm.nih.gov/pubmed/21850047
http://dx.doi.org/10.1038/cddis.2011.77
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author Jehle, J
Schweizer, P A
Katus, H A
Thomas, D
author_facet Jehle, J
Schweizer, P A
Katus, H A
Thomas, D
author_sort Jehle, J
collection PubMed
description The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular arrhythmias in humans. hERG K(+) channels are also expressed in a variety of cancer cells where they control cell proliferation and apoptosis. In this review, we discuss molecular mechanisms of hERG-associated cell cycle regulation and cell death. In addition, the significance of hERG K(+) channels as future drug target in anticancer therapy is highlighted.
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spelling pubmed-31814222011-10-20 Novel roles for hERG K(+) channels in cell proliferation and apoptosis Jehle, J Schweizer, P A Katus, H A Thomas, D Cell Death Dis Review The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular arrhythmias in humans. hERG K(+) channels are also expressed in a variety of cancer cells where they control cell proliferation and apoptosis. In this review, we discuss molecular mechanisms of hERG-associated cell cycle regulation and cell death. In addition, the significance of hERG K(+) channels as future drug target in anticancer therapy is highlighted. Nature Publishing Group 2011-08 2011-08-18 /pmc/articles/PMC3181422/ /pubmed/21850047 http://dx.doi.org/10.1038/cddis.2011.77 Text en Copyright © 2011 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Review
Jehle, J
Schweizer, P A
Katus, H A
Thomas, D
Novel roles for hERG K(+) channels in cell proliferation and apoptosis
title Novel roles for hERG K(+) channels in cell proliferation and apoptosis
title_full Novel roles for hERG K(+) channels in cell proliferation and apoptosis
title_fullStr Novel roles for hERG K(+) channels in cell proliferation and apoptosis
title_full_unstemmed Novel roles for hERG K(+) channels in cell proliferation and apoptosis
title_short Novel roles for hERG K(+) channels in cell proliferation and apoptosis
title_sort novel roles for herg k(+) channels in cell proliferation and apoptosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181422/
https://www.ncbi.nlm.nih.gov/pubmed/21850047
http://dx.doi.org/10.1038/cddis.2011.77
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