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Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links Cryptococcus neoformans Phenotype with Clinical Outcome

While a myriad of studies have examined host factors that predispose persons to infection with the opportunistic fungal pathogen Cryptococcus neoformans, comparatively little has been done to examine how virulence factor differences among cryptococcal isolates may impact outcome. In the recent repor...

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Detalles Bibliográficos
Autores principales: Mansour, Michael K., Vyas, Jatin M., Levitz, Stuart M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181469/
https://www.ncbi.nlm.nih.gov/pubmed/21954307
http://dx.doi.org/10.1128/mBio.00217-11
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author Mansour, Michael K.
Vyas, Jatin M.
Levitz, Stuart M.
author_facet Mansour, Michael K.
Vyas, Jatin M.
Levitz, Stuart M.
author_sort Mansour, Michael K.
collection PubMed
description While a myriad of studies have examined host factors that predispose persons to infection with the opportunistic fungal pathogen Cryptococcus neoformans, comparatively little has been done to examine how virulence factor differences among cryptococcal isolates may impact outcome. In the recent report by Alanio et al. (A. Alanio, M. Desnos-Ollivier, and F. Dromer, mBio 2:e00158-11, 2011), novel flow cytometry-based techniques were employed to demonstrate an association between the phenotype of C. neoformans-macrophage interactions, as measured by phagocytosis and intracellular replication, and patient outcomes, as determined by positive cultures on therapy and survival. These experiments establish that the prognosis of patients with cryptococcosis is influenced by the phenotypic properties of the infecting fungal isolate.
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spelling pubmed-31814692011-09-28 Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links Cryptococcus neoformans Phenotype with Clinical Outcome Mansour, Michael K. Vyas, Jatin M. Levitz, Stuart M. mBio Commentary While a myriad of studies have examined host factors that predispose persons to infection with the opportunistic fungal pathogen Cryptococcus neoformans, comparatively little has been done to examine how virulence factor differences among cryptococcal isolates may impact outcome. In the recent report by Alanio et al. (A. Alanio, M. Desnos-Ollivier, and F. Dromer, mBio 2:e00158-11, 2011), novel flow cytometry-based techniques were employed to demonstrate an association between the phenotype of C. neoformans-macrophage interactions, as measured by phagocytosis and intracellular replication, and patient outcomes, as determined by positive cultures on therapy and survival. These experiments establish that the prognosis of patients with cryptococcosis is influenced by the phenotypic properties of the infecting fungal isolate. American Society of Microbiology 2011-09-27 /pmc/articles/PMC3181469/ /pubmed/21954307 http://dx.doi.org/10.1128/mBio.00217-11 Text en Copyright © 2011 Mansour et al. http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-nc-sa/3.0/) , which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Commentary
Mansour, Michael K.
Vyas, Jatin M.
Levitz, Stuart M.
Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links Cryptococcus neoformans Phenotype with Clinical Outcome
title Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links Cryptococcus neoformans Phenotype with Clinical Outcome
title_full Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links Cryptococcus neoformans Phenotype with Clinical Outcome
title_fullStr Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links Cryptococcus neoformans Phenotype with Clinical Outcome
title_full_unstemmed Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links Cryptococcus neoformans Phenotype with Clinical Outcome
title_short Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links Cryptococcus neoformans Phenotype with Clinical Outcome
title_sort dynamic virulence: real-time assessment of intracellular pathogenesis links cryptococcus neoformans phenotype with clinical outcome
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181469/
https://www.ncbi.nlm.nih.gov/pubmed/21954307
http://dx.doi.org/10.1128/mBio.00217-11
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