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Neural models of schizophrenia
Hallucinations and delusions - two diagnostic features of psychosis shared across the spectrum of heterogeneous schizophrenia constructs - can be described in terms of the pathophysiology of sensory information processing: hallucination is the impaired ability to classify representations as internal...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Les Laboratoires Servier
2000
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181608/ https://www.ncbi.nlm.nih.gov/pubmed/22033839 |
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author | Heckers, Stephan |
author_facet | Heckers, Stephan |
author_sort | Heckers, Stephan |
collection | PubMed |
description | Hallucinations and delusions - two diagnostic features of psychosis shared across the spectrum of heterogeneous schizophrenia constructs - can be described in terms of the pathophysiology of sensory information processing: hallucination is the impaired ability to classify representations as internally or externally generated, while delusion is the immutable linking of representations with each other in the absence of external dependency. The key anatomical systems in higher-order information processing are the cortex, thalamus, basal ganglia, and medial temporal lobe, each of which is modulated by neurotransmitter projection systems. Preliminary evidence, concentrating to date on the dorsolateral prefontal cortex, thalamus, and hippocampal region of the medial temporal lobe, points to neural circuitry dysfunction within and between each system in psychosis. This may account for specific symptoms and associated cognitive deficits such as memory impairment, attention deficit, and language disturbance. |
format | Online Article Text |
id | pubmed-3181608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | Les Laboratoires Servier |
record_format | MEDLINE/PubMed |
spelling | pubmed-31816082011-10-27 Neural models of schizophrenia Heckers, Stephan Dialogues Clin Neurosci Basic Research Hallucinations and delusions - two diagnostic features of psychosis shared across the spectrum of heterogeneous schizophrenia constructs - can be described in terms of the pathophysiology of sensory information processing: hallucination is the impaired ability to classify representations as internally or externally generated, while delusion is the immutable linking of representations with each other in the absence of external dependency. The key anatomical systems in higher-order information processing are the cortex, thalamus, basal ganglia, and medial temporal lobe, each of which is modulated by neurotransmitter projection systems. Preliminary evidence, concentrating to date on the dorsolateral prefontal cortex, thalamus, and hippocampal region of the medial temporal lobe, points to neural circuitry dysfunction within and between each system in psychosis. This may account for specific symptoms and associated cognitive deficits such as memory impairment, attention deficit, and language disturbance. Les Laboratoires Servier 2000-09 /pmc/articles/PMC3181608/ /pubmed/22033839 Text en Copyright: © 2000 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Basic Research Heckers, Stephan Neural models of schizophrenia |
title | Neural models of schizophrenia |
title_full | Neural models of schizophrenia |
title_fullStr | Neural models of schizophrenia |
title_full_unstemmed | Neural models of schizophrenia |
title_short | Neural models of schizophrenia |
title_sort | neural models of schizophrenia |
topic | Basic Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181608/ https://www.ncbi.nlm.nih.gov/pubmed/22033839 |
work_keys_str_mv | AT heckersstephan neuralmodelsofschizophrenia |