Cargando…

Common genetic risk factors for psychiatric and simatic disorders

There is increasing knowledge about considerable comorbidity between psychiatric and somatic diseases, questioning whether variations in genes could be predisposing factors for both conditions. With respect to the multiple interactions between brain and body investigations have centered on variants...

Descripción completa

Detalles Bibliográficos
Autor principal: Bondy, Brigitta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181627/
https://www.ncbi.nlm.nih.gov/pubmed/22034450
_version_ 1782212776234582016
author Bondy, Brigitta
author_facet Bondy, Brigitta
author_sort Bondy, Brigitta
collection PubMed
description There is increasing knowledge about considerable comorbidity between psychiatric and somatic diseases, questioning whether variations in genes could be predisposing factors for both conditions. With respect to the multiple interactions between brain and body investigations have centered on variants in several candidate genes for proteins that mediate these interactions and therefore also have implications in psychiatric disorders. The available data, although still preliminary and rare, indicate the importance of polymorphic variants in genes coding for the serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT), the 5-HT(2A) receptor, proinflammatory cytokines, and the angiotensin-converting enzyme (ACE) in migraine, fibromyalgia, cardiovascular disorders, and psychiatric conditions. The role played by these various polymorphisms remains to be determined, as does whether they are indicative of common pathophysiological mechanisms or identify a subgroup of patients with somatic disorders that are more closely related to psychiatric symptoms. Nevertheless, they do at least illustrate the potential influence of genetic differences on illness course and treatment outcome, and might be a rational approach to drug development and treatment paradigms.
format Online
Article
Text
id pubmed-3181627
institution National Center for Biotechnology Information
language English
publishDate 2003
publisher Les Laboratoires Servier
record_format MEDLINE/PubMed
spelling pubmed-31816272011-10-27 Common genetic risk factors for psychiatric and simatic disorders Bondy, Brigitta Dialogues Clin Neurosci Basic Research There is increasing knowledge about considerable comorbidity between psychiatric and somatic diseases, questioning whether variations in genes could be predisposing factors for both conditions. With respect to the multiple interactions between brain and body investigations have centered on variants in several candidate genes for proteins that mediate these interactions and therefore also have implications in psychiatric disorders. The available data, although still preliminary and rare, indicate the importance of polymorphic variants in genes coding for the serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT), the 5-HT(2A) receptor, proinflammatory cytokines, and the angiotensin-converting enzyme (ACE) in migraine, fibromyalgia, cardiovascular disorders, and psychiatric conditions. The role played by these various polymorphisms remains to be determined, as does whether they are indicative of common pathophysiological mechanisms or identify a subgroup of patients with somatic disorders that are more closely related to psychiatric symptoms. Nevertheless, they do at least illustrate the potential influence of genetic differences on illness course and treatment outcome, and might be a rational approach to drug development and treatment paradigms. Les Laboratoires Servier 2003-06 /pmc/articles/PMC3181627/ /pubmed/22034450 Text en Copyright: © 2003 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Basic Research
Bondy, Brigitta
Common genetic risk factors for psychiatric and simatic disorders
title Common genetic risk factors for psychiatric and simatic disorders
title_full Common genetic risk factors for psychiatric and simatic disorders
title_fullStr Common genetic risk factors for psychiatric and simatic disorders
title_full_unstemmed Common genetic risk factors for psychiatric and simatic disorders
title_short Common genetic risk factors for psychiatric and simatic disorders
title_sort common genetic risk factors for psychiatric and simatic disorders
topic Basic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181627/
https://www.ncbi.nlm.nih.gov/pubmed/22034450
work_keys_str_mv AT bondybrigitta commongeneticriskfactorsforpsychiatricandsimaticdisorders