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Common genetic risk factors for psychiatric and simatic disorders
There is increasing knowledge about considerable comorbidity between psychiatric and somatic diseases, questioning whether variations in genes could be predisposing factors for both conditions. With respect to the multiple interactions between brain and body investigations have centered on variants...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Les Laboratoires Servier
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181627/ https://www.ncbi.nlm.nih.gov/pubmed/22034450 |
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author | Bondy, Brigitta |
author_facet | Bondy, Brigitta |
author_sort | Bondy, Brigitta |
collection | PubMed |
description | There is increasing knowledge about considerable comorbidity between psychiatric and somatic diseases, questioning whether variations in genes could be predisposing factors for both conditions. With respect to the multiple interactions between brain and body investigations have centered on variants in several candidate genes for proteins that mediate these interactions and therefore also have implications in psychiatric disorders. The available data, although still preliminary and rare, indicate the importance of polymorphic variants in genes coding for the serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT), the 5-HT(2A) receptor, proinflammatory cytokines, and the angiotensin-converting enzyme (ACE) in migraine, fibromyalgia, cardiovascular disorders, and psychiatric conditions. The role played by these various polymorphisms remains to be determined, as does whether they are indicative of common pathophysiological mechanisms or identify a subgroup of patients with somatic disorders that are more closely related to psychiatric symptoms. Nevertheless, they do at least illustrate the potential influence of genetic differences on illness course and treatment outcome, and might be a rational approach to drug development and treatment paradigms. |
format | Online Article Text |
id | pubmed-3181627 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | Les Laboratoires Servier |
record_format | MEDLINE/PubMed |
spelling | pubmed-31816272011-10-27 Common genetic risk factors for psychiatric and simatic disorders Bondy, Brigitta Dialogues Clin Neurosci Basic Research There is increasing knowledge about considerable comorbidity between psychiatric and somatic diseases, questioning whether variations in genes could be predisposing factors for both conditions. With respect to the multiple interactions between brain and body investigations have centered on variants in several candidate genes for proteins that mediate these interactions and therefore also have implications in psychiatric disorders. The available data, although still preliminary and rare, indicate the importance of polymorphic variants in genes coding for the serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT), the 5-HT(2A) receptor, proinflammatory cytokines, and the angiotensin-converting enzyme (ACE) in migraine, fibromyalgia, cardiovascular disorders, and psychiatric conditions. The role played by these various polymorphisms remains to be determined, as does whether they are indicative of common pathophysiological mechanisms or identify a subgroup of patients with somatic disorders that are more closely related to psychiatric symptoms. Nevertheless, they do at least illustrate the potential influence of genetic differences on illness course and treatment outcome, and might be a rational approach to drug development and treatment paradigms. Les Laboratoires Servier 2003-06 /pmc/articles/PMC3181627/ /pubmed/22034450 Text en Copyright: © 2003 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Basic Research Bondy, Brigitta Common genetic risk factors for psychiatric and simatic disorders |
title | Common genetic risk factors for psychiatric and simatic disorders |
title_full | Common genetic risk factors for psychiatric and simatic disorders |
title_fullStr | Common genetic risk factors for psychiatric and simatic disorders |
title_full_unstemmed | Common genetic risk factors for psychiatric and simatic disorders |
title_short | Common genetic risk factors for psychiatric and simatic disorders |
title_sort | common genetic risk factors for psychiatric and simatic disorders |
topic | Basic Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181627/ https://www.ncbi.nlm.nih.gov/pubmed/22034450 |
work_keys_str_mv | AT bondybrigitta commongeneticriskfactorsforpsychiatricandsimaticdisorders |