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Combination pharmacotherapy in Alzheimer's disease
Alzheimer's disease is a progressive, debilitating form of dementia affecting more than 18 million people worldwide. Without a cure, many patients and their families must turn to long-term care institutions during the later stages of the disease. Our current treatments only delay progression an...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Les Laboratoires Servier
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181636/ https://www.ncbi.nlm.nih.gov/pubmed/22033825 |
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author | Mintzer, Jacobo Armstrong, Dena Faison, Warachal E. |
author_facet | Mintzer, Jacobo Armstrong, Dena Faison, Warachal E. |
author_sort | Mintzer, Jacobo |
collection | PubMed |
description | Alzheimer's disease is a progressive, debilitating form of dementia affecting more than 18 million people worldwide. Without a cure, many patients and their families must turn to long-term care institutions during the later stages of the disease. Our current treatments only delay progression and help control behavioral symptoms. In recent years, research within this field has expanded to include many clinical trials on potential drug therapies. However, despite the numerous studies, the enigma of this disease remains. It is difficult yet necessary, to stay abreast of emerging information that may warrant changes in current therapy. Rationale for combination therapy becomes evident as we review the multiple neurochemical pathways common to the disease. This paper will review available information on Alzheimer's disease pharmacotherapy, and evaluate data on the use of combination drug therapy. Individual efficacy, possible synergistic effects, and the safety of combination therapy will also be addressed. |
format | Online Article Text |
id | pubmed-3181636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | Les Laboratoires Servier |
record_format | MEDLINE/PubMed |
spelling | pubmed-31816362011-10-27 Combination pharmacotherapy in Alzheimer's disease Mintzer, Jacobo Armstrong, Dena Faison, Warachal E. Dialogues Clin Neurosci Free Paper Alzheimer's disease is a progressive, debilitating form of dementia affecting more than 18 million people worldwide. Without a cure, many patients and their families must turn to long-term care institutions during the later stages of the disease. Our current treatments only delay progression and help control behavioral symptoms. In recent years, research within this field has expanded to include many clinical trials on potential drug therapies. However, despite the numerous studies, the enigma of this disease remains. It is difficult yet necessary, to stay abreast of emerging information that may warrant changes in current therapy. Rationale for combination therapy becomes evident as we review the multiple neurochemical pathways common to the disease. This paper will review available information on Alzheimer's disease pharmacotherapy, and evaluate data on the use of combination drug therapy. Individual efficacy, possible synergistic effects, and the safety of combination therapy will also be addressed. Les Laboratoires Servier 2003-09 /pmc/articles/PMC3181636/ /pubmed/22033825 Text en Copyright: © 2003 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Free Paper Mintzer, Jacobo Armstrong, Dena Faison, Warachal E. Combination pharmacotherapy in Alzheimer's disease |
title | Combination pharmacotherapy in Alzheimer's disease |
title_full | Combination pharmacotherapy in Alzheimer's disease |
title_fullStr | Combination pharmacotherapy in Alzheimer's disease |
title_full_unstemmed | Combination pharmacotherapy in Alzheimer's disease |
title_short | Combination pharmacotherapy in Alzheimer's disease |
title_sort | combination pharmacotherapy in alzheimer's disease |
topic | Free Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181636/ https://www.ncbi.nlm.nih.gov/pubmed/22033825 |
work_keys_str_mv | AT mintzerjacobo combinationpharmacotherapyinalzheimersdisease AT armstrongdena combinationpharmacotherapyinalzheimersdisease AT faisonwarachale combinationpharmacotherapyinalzheimersdisease |