Challenges in the development of clinical trials for major depressive disorder: lessons learned from trials in minor depression

This paper reviews some of the challenges faced by individuals who design and implement clinical trials of potential antidepressant medications. Particular emphasis is placed on questioning the validity of some of the theoretical assumptions that form the underpinnings of most conventional trials. W...

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Detalles Bibliográficos
Autores principales: Rapaport, Mark H., Maddux, Rachel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2002
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181702/
https://www.ncbi.nlm.nih.gov/pubmed/22034443
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author Rapaport, Mark H.
Maddux, Rachel E.
author_facet Rapaport, Mark H.
Maddux, Rachel E.
author_sort Rapaport, Mark H.
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description This paper reviews some of the challenges faced by individuals who design and implement clinical trials of potential antidepressant medications. Particular emphasis is placed on questioning the validity of some of the theoretical assumptions that form the underpinnings of most conventional trials. Work from our group developing clinical trial methodology for minor depression is used as an example of how alternate constructs may be helpful to differentiate drug-placebo differences.
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spelling pubmed-31817022011-10-27 Challenges in the development of clinical trials for major depressive disorder: lessons learned from trials in minor depression Rapaport, Mark H. Maddux, Rachel E. Dialogues Clin Neurosci Clinical Research This paper reviews some of the challenges faced by individuals who design and implement clinical trials of potential antidepressant medications. Particular emphasis is placed on questioning the validity of some of the theoretical assumptions that form the underpinnings of most conventional trials. Work from our group developing clinical trial methodology for minor depression is used as an example of how alternate constructs may be helpful to differentiate drug-placebo differences. Les Laboratoires Servier 2002-12 /pmc/articles/PMC3181702/ /pubmed/22034443 Text en Copyright: © 2002 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research
Rapaport, Mark H.
Maddux, Rachel E.
Challenges in the development of clinical trials for major depressive disorder: lessons learned from trials in minor depression
title Challenges in the development of clinical trials for major depressive disorder: lessons learned from trials in minor depression
title_full Challenges in the development of clinical trials for major depressive disorder: lessons learned from trials in minor depression
title_fullStr Challenges in the development of clinical trials for major depressive disorder: lessons learned from trials in minor depression
title_full_unstemmed Challenges in the development of clinical trials for major depressive disorder: lessons learned from trials in minor depression
title_short Challenges in the development of clinical trials for major depressive disorder: lessons learned from trials in minor depression
title_sort challenges in the development of clinical trials for major depressive disorder: lessons learned from trials in minor depression
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181702/
https://www.ncbi.nlm.nih.gov/pubmed/22034443
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