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Contribution of sleep research to the development of new antidepressants
Several sleep anomalies are known to accompany depression and other psychiatric disorders, and to be partially modified by drugs efficient on clinical symptoms. Many puzzling theoretical questions remain, even after 30 years of research, because these drugs do not act in a uniform way: some reduce s...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Les Laboratoires Servier
2005
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181744/ https://www.ncbi.nlm.nih.gov/pubmed/16416706 |
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author | Le Bon, Olivier |
author_facet | Le Bon, Olivier |
author_sort | Le Bon, Olivier |
collection | PubMed |
description | Several sleep anomalies are known to accompany depression and other psychiatric disorders, and to be partially modified by drugs efficient on clinical symptoms. Many puzzling theoretical questions remain, even after 30 years of research, because these drugs do not act in a uniform way: some reduce slow-wave sleep while others increase it; some prolong rapid-eye movement sleep latency while others do not. The relationship between insomnia and depression is likely to be a close one, since a large majority of patients with depression suffer insomnia, and that insomnia can predate depression by a few years. However, questions remain here, too, since sleep deprivation is also an effective means to combat depression, and some patients present with hypersomnia rather than insomnia. This review details the action of all current classes of antidepressants on sleep. It examines the predictive value of baseline electronencephalographic sleep symptoms or early modifications due to treatment for eventual clinical efficiency. We will also discuss the two main theories on the relationship between sleep and depression. The action on sleep of all new drugs- and antidepressants in particular - is carefully examined during development, for insomnia is currently considered to be a major health concern in industrialized countries. |
format | Online Article Text |
id | pubmed-3181744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Les Laboratoires Servier |
record_format | MEDLINE/PubMed |
spelling | pubmed-31817442011-10-27 Contribution of sleep research to the development of new antidepressants Le Bon, Olivier Dialogues Clin Neurosci Basic Research Several sleep anomalies are known to accompany depression and other psychiatric disorders, and to be partially modified by drugs efficient on clinical symptoms. Many puzzling theoretical questions remain, even after 30 years of research, because these drugs do not act in a uniform way: some reduce slow-wave sleep while others increase it; some prolong rapid-eye movement sleep latency while others do not. The relationship between insomnia and depression is likely to be a close one, since a large majority of patients with depression suffer insomnia, and that insomnia can predate depression by a few years. However, questions remain here, too, since sleep deprivation is also an effective means to combat depression, and some patients present with hypersomnia rather than insomnia. This review details the action of all current classes of antidepressants on sleep. It examines the predictive value of baseline electronencephalographic sleep symptoms or early modifications due to treatment for eventual clinical efficiency. We will also discuss the two main theories on the relationship between sleep and depression. The action on sleep of all new drugs- and antidepressants in particular - is carefully examined during development, for insomnia is currently considered to be a major health concern in industrialized countries. Les Laboratoires Servier 2005-12 /pmc/articles/PMC3181744/ /pubmed/16416706 Text en Copyright: © 2005 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Basic Research Le Bon, Olivier Contribution of sleep research to the development of new antidepressants |
title | Contribution of sleep research to the development of new antidepressants |
title_full | Contribution of sleep research to the development of new antidepressants |
title_fullStr | Contribution of sleep research to the development of new antidepressants |
title_full_unstemmed | Contribution of sleep research to the development of new antidepressants |
title_short | Contribution of sleep research to the development of new antidepressants |
title_sort | contribution of sleep research to the development of new antidepressants |
topic | Basic Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181744/ https://www.ncbi.nlm.nih.gov/pubmed/16416706 |
work_keys_str_mv | AT lebonolivier contributionofsleepresearchtothedevelopmentofnewantidepressants |