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Cellular abnormalities in depression: evidence from postmortem brain tissue

During the past two decades, in vivo neuroimaging studies have permitted significant insights into the general location of dysfunctional brain regions in depression. In parallel and often intersecting ways, neuroanatomical, pharmacological, and biochemical studies of postmortem brain tissue are perm...

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Detalles Bibliográficos
Autores principales: Stockmeier, Craig A., Rajkowska, Grazyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181793/
https://www.ncbi.nlm.nih.gov/pubmed/22033633
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author Stockmeier, Craig A.
Rajkowska, Grazyna
author_facet Stockmeier, Craig A.
Rajkowska, Grazyna
author_sort Stockmeier, Craig A.
collection PubMed
description During the past two decades, in vivo neuroimaging studies have permitted significant insights into the general location of dysfunctional brain regions in depression. In parallel and often intersecting ways, neuroanatomical, pharmacological, and biochemical studies of postmortem brain tissue are permitting new insights into the pathophysiology of depression. In addition to long-recognized neurochemical abnormalities in depression, novel studies at the microscopic level support the contention that mood disorders are associated with abnormalities in cell morphology and distribution. In the past 6 years, cell-counting studies have identified changes in the density and size of both neurons and glia in a number of frontolimbic brain regions, including dorsolateral prefrontal, orbitofrontal, and anterior cingulate cortex, and the amygdala and hippocampus. Convergence of cellular changes at the microscopic level with neuroimaging changes detected in vivo provides a compelling integration of clinical and basic research for disentangling the pathophysiology of depression. The ultimate integration of these two research approaches will occur with premortem longitudinal clinical studies on well-characterized patients linked to postmortem studies of the same subjects.
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spelling pubmed-31817932011-10-27 Cellular abnormalities in depression: evidence from postmortem brain tissue Stockmeier, Craig A. Rajkowska, Grazyna Dialogues Clin Neurosci Clinical Research During the past two decades, in vivo neuroimaging studies have permitted significant insights into the general location of dysfunctional brain regions in depression. In parallel and often intersecting ways, neuroanatomical, pharmacological, and biochemical studies of postmortem brain tissue are permitting new insights into the pathophysiology of depression. In addition to long-recognized neurochemical abnormalities in depression, novel studies at the microscopic level support the contention that mood disorders are associated with abnormalities in cell morphology and distribution. In the past 6 years, cell-counting studies have identified changes in the density and size of both neurons and glia in a number of frontolimbic brain regions, including dorsolateral prefrontal, orbitofrontal, and anterior cingulate cortex, and the amygdala and hippocampus. Convergence of cellular changes at the microscopic level with neuroimaging changes detected in vivo provides a compelling integration of clinical and basic research for disentangling the pathophysiology of depression. The ultimate integration of these two research approaches will occur with premortem longitudinal clinical studies on well-characterized patients linked to postmortem studies of the same subjects. Les Laboratoires Servier 2004-06 /pmc/articles/PMC3181793/ /pubmed/22033633 Text en Copyright: © 2004 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research
Stockmeier, Craig A.
Rajkowska, Grazyna
Cellular abnormalities in depression: evidence from postmortem brain tissue
title Cellular abnormalities in depression: evidence from postmortem brain tissue
title_full Cellular abnormalities in depression: evidence from postmortem brain tissue
title_fullStr Cellular abnormalities in depression: evidence from postmortem brain tissue
title_full_unstemmed Cellular abnormalities in depression: evidence from postmortem brain tissue
title_short Cellular abnormalities in depression: evidence from postmortem brain tissue
title_sort cellular abnormalities in depression: evidence from postmortem brain tissue
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181793/
https://www.ncbi.nlm.nih.gov/pubmed/22033633
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