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Cognitive neuroscience and brain imaging in bipolar disorder

Bipolar disorder is characterized by a combination of state-related changes in psychological functíon that are restricted to illness episodes, coupled with trait-related changes that persist through periods of remission, irrespective of symptom status. This article reviews studies that have investig...

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Autores principales: Clark, Luke, Sahakian, Barbara J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181872/
https://www.ncbi.nlm.nih.gov/pubmed/18689286
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author Clark, Luke
Sahakian, Barbara J.
author_facet Clark, Luke
Sahakian, Barbara J.
author_sort Clark, Luke
collection PubMed
description Bipolar disorder is characterized by a combination of state-related changes in psychological functíon that are restricted to illness episodes, coupled with trait-related changes that persist through periods of remission, irrespective of symptom status. This article reviews studies that have investigated the brain systems involved in these state-and trait-related changes, using two techniques: (i) indirect measures of neurocognitive function, and (ii) direct neuroimaging measures of brain function during performance of a cognitive task. Studies of neurocognitive function in bipolar disorder indicate deficits in three core domains: attention, executive function, and emotional processing. Functional imaging studies implicate pathophysiology in distributed neural circuitry that includes the prefrontal and anterior cingulate cortices, as well as subcortical limbic structures including the amygdala and the ventral striatum. Whilst there have been clear advances in our understanding of brain changes in bipolar disorder, there are limited data in bipolar depression, and there is limited understanding of the influence of clinical variables including medication status, illness severity, and specific symptom dimensions.
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spelling pubmed-31818722011-10-27 Cognitive neuroscience and brain imaging in bipolar disorder Clark, Luke Sahakian, Barbara J. Dialogues Clin Neurosci Translational Research Bipolar disorder is characterized by a combination of state-related changes in psychological functíon that are restricted to illness episodes, coupled with trait-related changes that persist through periods of remission, irrespective of symptom status. This article reviews studies that have investigated the brain systems involved in these state-and trait-related changes, using two techniques: (i) indirect measures of neurocognitive function, and (ii) direct neuroimaging measures of brain function during performance of a cognitive task. Studies of neurocognitive function in bipolar disorder indicate deficits in three core domains: attention, executive function, and emotional processing. Functional imaging studies implicate pathophysiology in distributed neural circuitry that includes the prefrontal and anterior cingulate cortices, as well as subcortical limbic structures including the amygdala and the ventral striatum. Whilst there have been clear advances in our understanding of brain changes in bipolar disorder, there are limited data in bipolar depression, and there is limited understanding of the influence of clinical variables including medication status, illness severity, and specific symptom dimensions. Les Laboratoires Servier 2008-06 /pmc/articles/PMC3181872/ /pubmed/18689286 Text en Copyright: © 2008 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Translational Research
Clark, Luke
Sahakian, Barbara J.
Cognitive neuroscience and brain imaging in bipolar disorder
title Cognitive neuroscience and brain imaging in bipolar disorder
title_full Cognitive neuroscience and brain imaging in bipolar disorder
title_fullStr Cognitive neuroscience and brain imaging in bipolar disorder
title_full_unstemmed Cognitive neuroscience and brain imaging in bipolar disorder
title_short Cognitive neuroscience and brain imaging in bipolar disorder
title_sort cognitive neuroscience and brain imaging in bipolar disorder
topic Translational Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181872/
https://www.ncbi.nlm.nih.gov/pubmed/18689286
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