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Neuroplasticity in addictive disorders

Compulsive drug-taking behavior develops in vulnerable individuals who ingest substances that activate the reward system. This intense activation produces learned associations to cues that predict drug availability. With repetition the reward system becomes reflexively activated by cues alone, leadi...

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Detalles Bibliográficos
Autor principal: O'Brien, Charles P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181920/
https://www.ncbi.nlm.nih.gov/pubmed/19877501
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author O'Brien, Charles P.
author_facet O'Brien, Charles P.
author_sort O'Brien, Charles P.
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description Compulsive drug-taking behavior develops in vulnerable individuals who ingest substances that activate the reward system. This intense activation produces learned associations to cues that predict drug availability. With repetition the reward system becomes reflexively activated by cues alone, leading to a drive toward drug-taking. The central nervous system changes underlying this conditioned behavior are just beginning to be understood. New treatments aimed at this neuroplasticity are being tested in animal models. The clinical significance of these brain changes is that addiction, once established, becomes a chronic illness with relapses and remissions, it therefore requires chronic treatment with medications and behavioral therapies based on an understanding of the fundamental nature of these changes in the brain.
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spelling pubmed-31819202011-10-27 Neuroplasticity in addictive disorders O'Brien, Charles P. Dialogues Clin Neurosci Brief Report Compulsive drug-taking behavior develops in vulnerable individuals who ingest substances that activate the reward system. This intense activation produces learned associations to cues that predict drug availability. With repetition the reward system becomes reflexively activated by cues alone, leading to a drive toward drug-taking. The central nervous system changes underlying this conditioned behavior are just beginning to be understood. New treatments aimed at this neuroplasticity are being tested in animal models. The clinical significance of these brain changes is that addiction, once established, becomes a chronic illness with relapses and remissions, it therefore requires chronic treatment with medications and behavioral therapies based on an understanding of the fundamental nature of these changes in the brain. Les Laboratoires Servier 2009-09 /pmc/articles/PMC3181920/ /pubmed/19877501 Text en Copyright: © 2009 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
O'Brien, Charles P.
Neuroplasticity in addictive disorders
title Neuroplasticity in addictive disorders
title_full Neuroplasticity in addictive disorders
title_fullStr Neuroplasticity in addictive disorders
title_full_unstemmed Neuroplasticity in addictive disorders
title_short Neuroplasticity in addictive disorders
title_sort neuroplasticity in addictive disorders
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181920/
https://www.ncbi.nlm.nih.gov/pubmed/19877501
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