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Neuroplasticity in addictive disorders
Compulsive drug-taking behavior develops in vulnerable individuals who ingest substances that activate the reward system. This intense activation produces learned associations to cues that predict drug availability. With repetition the reward system becomes reflexively activated by cues alone, leadi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Les Laboratoires Servier
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181920/ https://www.ncbi.nlm.nih.gov/pubmed/19877501 |
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author | O'Brien, Charles P. |
author_facet | O'Brien, Charles P. |
author_sort | O'Brien, Charles P. |
collection | PubMed |
description | Compulsive drug-taking behavior develops in vulnerable individuals who ingest substances that activate the reward system. This intense activation produces learned associations to cues that predict drug availability. With repetition the reward system becomes reflexively activated by cues alone, leading to a drive toward drug-taking. The central nervous system changes underlying this conditioned behavior are just beginning to be understood. New treatments aimed at this neuroplasticity are being tested in animal models. The clinical significance of these brain changes is that addiction, once established, becomes a chronic illness with relapses and remissions, it therefore requires chronic treatment with medications and behavioral therapies based on an understanding of the fundamental nature of these changes in the brain. |
format | Online Article Text |
id | pubmed-3181920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Les Laboratoires Servier |
record_format | MEDLINE/PubMed |
spelling | pubmed-31819202011-10-27 Neuroplasticity in addictive disorders O'Brien, Charles P. Dialogues Clin Neurosci Brief Report Compulsive drug-taking behavior develops in vulnerable individuals who ingest substances that activate the reward system. This intense activation produces learned associations to cues that predict drug availability. With repetition the reward system becomes reflexively activated by cues alone, leading to a drive toward drug-taking. The central nervous system changes underlying this conditioned behavior are just beginning to be understood. New treatments aimed at this neuroplasticity are being tested in animal models. The clinical significance of these brain changes is that addiction, once established, becomes a chronic illness with relapses and remissions, it therefore requires chronic treatment with medications and behavioral therapies based on an understanding of the fundamental nature of these changes in the brain. Les Laboratoires Servier 2009-09 /pmc/articles/PMC3181920/ /pubmed/19877501 Text en Copyright: © 2009 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report O'Brien, Charles P. Neuroplasticity in addictive disorders |
title | Neuroplasticity in addictive disorders |
title_full | Neuroplasticity in addictive disorders |
title_fullStr | Neuroplasticity in addictive disorders |
title_full_unstemmed | Neuroplasticity in addictive disorders |
title_short | Neuroplasticity in addictive disorders |
title_sort | neuroplasticity in addictive disorders |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181920/ https://www.ncbi.nlm.nih.gov/pubmed/19877501 |
work_keys_str_mv | AT obriencharlesp neuroplasticityinaddictivedisorders |