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SPECT assessment of brain activation induced by caffeine: no effect on areas involved in dependence

Caffeine is not considered addictive, and in animals it does not trigger metabolic increases or dopamine release in brain areas involved in reinforcement and reward. Our objective was to measure caffeine effects on cerebral perfusion in humans using single photon emission computed tomography, with a...

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Autores principales: Nehlig, Astrid, Armspach, Jean-Paul, Namer, Izzie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181952/
https://www.ncbi.nlm.nih.gov/pubmed/20623930
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author Nehlig, Astrid
Armspach, Jean-Paul
Namer, Izzie J.
author_facet Nehlig, Astrid
Armspach, Jean-Paul
Namer, Izzie J.
author_sort Nehlig, Astrid
collection PubMed
description Caffeine is not considered addictive, and in animals it does not trigger metabolic increases or dopamine release in brain areas involved in reinforcement and reward. Our objective was to measure caffeine effects on cerebral perfusion in humans using single photon emission computed tomography, with a specific focus on areas of reinforcement and reward. Two groups of nonsmoking subjects were studied, one with a low (8 subjects) and one with a high (6 subjects) daily coffee consumption. The subjects ingested 3 mg/kg caffeine or placebo in a raspberry-tasting drink, and scans were performed 45 min after ingestion. A control group of 12 healthy volunteers receiving no drink was also studied. Caffeine consumption led to a generalized, statistically nonsignificant perfusion decrease of 6% to 8%, comparable in low and high consumers. Compared with controls, low consumers displayed neuronal activation bilaterally in inferior frontal gyrusanterior insular cortex and uncus, left internal parietal cortex, right lingual gyrus, and cerebellum. In high consumers, brain activation occurred bilaterally only in hypothalamus. Thus, on a background of widespread low-amplitude perfusion decrease, caffeine activates a few regions mainly involved in the control of vigilance, anxiety, and cardiovascular regulation, but does not affect areas involved in reinforcing and reward.
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spelling pubmed-31819522011-10-27 SPECT assessment of brain activation induced by caffeine: no effect on areas involved in dependence Nehlig, Astrid Armspach, Jean-Paul Namer, Izzie J. Dialogues Clin Neurosci Free Paper Caffeine is not considered addictive, and in animals it does not trigger metabolic increases or dopamine release in brain areas involved in reinforcement and reward. Our objective was to measure caffeine effects on cerebral perfusion in humans using single photon emission computed tomography, with a specific focus on areas of reinforcement and reward. Two groups of nonsmoking subjects were studied, one with a low (8 subjects) and one with a high (6 subjects) daily coffee consumption. The subjects ingested 3 mg/kg caffeine or placebo in a raspberry-tasting drink, and scans were performed 45 min after ingestion. A control group of 12 healthy volunteers receiving no drink was also studied. Caffeine consumption led to a generalized, statistically nonsignificant perfusion decrease of 6% to 8%, comparable in low and high consumers. Compared with controls, low consumers displayed neuronal activation bilaterally in inferior frontal gyrusanterior insular cortex and uncus, left internal parietal cortex, right lingual gyrus, and cerebellum. In high consumers, brain activation occurred bilaterally only in hypothalamus. Thus, on a background of widespread low-amplitude perfusion decrease, caffeine activates a few regions mainly involved in the control of vigilance, anxiety, and cardiovascular regulation, but does not affect areas involved in reinforcing and reward. Les Laboratoires Servier 2010-06 /pmc/articles/PMC3181952/ /pubmed/20623930 Text en Copyright: © 2010 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Free Paper
Nehlig, Astrid
Armspach, Jean-Paul
Namer, Izzie J.
SPECT assessment of brain activation induced by caffeine: no effect on areas involved in dependence
title SPECT assessment of brain activation induced by caffeine: no effect on areas involved in dependence
title_full SPECT assessment of brain activation induced by caffeine: no effect on areas involved in dependence
title_fullStr SPECT assessment of brain activation induced by caffeine: no effect on areas involved in dependence
title_full_unstemmed SPECT assessment of brain activation induced by caffeine: no effect on areas involved in dependence
title_short SPECT assessment of brain activation induced by caffeine: no effect on areas involved in dependence
title_sort spect assessment of brain activation induced by caffeine: no effect on areas involved in dependence
topic Free Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181952/
https://www.ncbi.nlm.nih.gov/pubmed/20623930
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