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Translational neuroimaging research in pediatric obsessive-compulsive disorder
Obsessive-compulsive disorder (OCD) is a significant public health problem. Selective serotonin reuptake inhibitors (SSRIs) are the only FDA-approved medications for OCD. However, SSRIs are of limited efficacy in clinical practice. Given the persistence of symptoms and levels of treatment response,...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Les Laboratoires Servier
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181954/ https://www.ncbi.nlm.nih.gov/pubmed/20623921 |
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author | Mac Master, Frank P. |
author_facet | Mac Master, Frank P. |
author_sort | Mac Master, Frank P. |
collection | PubMed |
description | Obsessive-compulsive disorder (OCD) is a significant public health problem. Selective serotonin reuptake inhibitors (SSRIs) are the only FDA-approved medications for OCD. However, SSRIs are of limited efficacy in clinical practice. Given the persistence of symptoms and levels of treatment response, it is clear that the serotonin paradigm of OCD does not fully account for the neurobiology of the disorder, and that further translational research is needed. In this review, the glutamate hypothesis of pediatric OCD is explored, the neuroimaging evidence reviewed, and the translational impact highlighted. The traditional strategy of going from pharmacology to pathophysiology has failed to show real progress in our understanding of the neurobiology of psychiatric illness and, while still in the early stages, this work demonstrates the clear benefit of approaching psychiatric illness from the opposite direction. |
format | Online Article Text |
id | pubmed-3181954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Les Laboratoires Servier |
record_format | MEDLINE/PubMed |
spelling | pubmed-31819542011-10-27 Translational neuroimaging research in pediatric obsessive-compulsive disorder Mac Master, Frank P. Dialogues Clin Neurosci Translational Research Obsessive-compulsive disorder (OCD) is a significant public health problem. Selective serotonin reuptake inhibitors (SSRIs) are the only FDA-approved medications for OCD. However, SSRIs are of limited efficacy in clinical practice. Given the persistence of symptoms and levels of treatment response, it is clear that the serotonin paradigm of OCD does not fully account for the neurobiology of the disorder, and that further translational research is needed. In this review, the glutamate hypothesis of pediatric OCD is explored, the neuroimaging evidence reviewed, and the translational impact highlighted. The traditional strategy of going from pharmacology to pathophysiology has failed to show real progress in our understanding of the neurobiology of psychiatric illness and, while still in the early stages, this work demonstrates the clear benefit of approaching psychiatric illness from the opposite direction. Les Laboratoires Servier 2010-06 /pmc/articles/PMC3181954/ /pubmed/20623921 Text en Copyright: © 2010 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Translational Research Mac Master, Frank P. Translational neuroimaging research in pediatric obsessive-compulsive disorder |
title | Translational neuroimaging research in pediatric obsessive-compulsive disorder |
title_full | Translational neuroimaging research in pediatric obsessive-compulsive disorder |
title_fullStr | Translational neuroimaging research in pediatric obsessive-compulsive disorder |
title_full_unstemmed | Translational neuroimaging research in pediatric obsessive-compulsive disorder |
title_short | Translational neuroimaging research in pediatric obsessive-compulsive disorder |
title_sort | translational neuroimaging research in pediatric obsessive-compulsive disorder |
topic | Translational Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181954/ https://www.ncbi.nlm.nih.gov/pubmed/20623921 |
work_keys_str_mv | AT macmasterfrankp translationalneuroimagingresearchinpediatricobsessivecompulsivedisorder |