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Translational neuroimaging research in pediatric obsessive-compulsive disorder

Obsessive-compulsive disorder (OCD) is a significant public health problem. Selective serotonin reuptake inhibitors (SSRIs) are the only FDA-approved medications for OCD. However, SSRIs are of limited efficacy in clinical practice. Given the persistence of symptoms and levels of treatment response,...

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Autor principal: Mac Master, Frank P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181954/
https://www.ncbi.nlm.nih.gov/pubmed/20623921
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author Mac Master, Frank P.
author_facet Mac Master, Frank P.
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description Obsessive-compulsive disorder (OCD) is a significant public health problem. Selective serotonin reuptake inhibitors (SSRIs) are the only FDA-approved medications for OCD. However, SSRIs are of limited efficacy in clinical practice. Given the persistence of symptoms and levels of treatment response, it is clear that the serotonin paradigm of OCD does not fully account for the neurobiology of the disorder, and that further translational research is needed. In this review, the glutamate hypothesis of pediatric OCD is explored, the neuroimaging evidence reviewed, and the translational impact highlighted. The traditional strategy of going from pharmacology to pathophysiology has failed to show real progress in our understanding of the neurobiology of psychiatric illness and, while still in the early stages, this work demonstrates the clear benefit of approaching psychiatric illness from the opposite direction.
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spelling pubmed-31819542011-10-27 Translational neuroimaging research in pediatric obsessive-compulsive disorder Mac Master, Frank P. Dialogues Clin Neurosci Translational Research Obsessive-compulsive disorder (OCD) is a significant public health problem. Selective serotonin reuptake inhibitors (SSRIs) are the only FDA-approved medications for OCD. However, SSRIs are of limited efficacy in clinical practice. Given the persistence of symptoms and levels of treatment response, it is clear that the serotonin paradigm of OCD does not fully account for the neurobiology of the disorder, and that further translational research is needed. In this review, the glutamate hypothesis of pediatric OCD is explored, the neuroimaging evidence reviewed, and the translational impact highlighted. The traditional strategy of going from pharmacology to pathophysiology has failed to show real progress in our understanding of the neurobiology of psychiatric illness and, while still in the early stages, this work demonstrates the clear benefit of approaching psychiatric illness from the opposite direction. Les Laboratoires Servier 2010-06 /pmc/articles/PMC3181954/ /pubmed/20623921 Text en Copyright: © 2010 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Translational Research
Mac Master, Frank P.
Translational neuroimaging research in pediatric obsessive-compulsive disorder
title Translational neuroimaging research in pediatric obsessive-compulsive disorder
title_full Translational neuroimaging research in pediatric obsessive-compulsive disorder
title_fullStr Translational neuroimaging research in pediatric obsessive-compulsive disorder
title_full_unstemmed Translational neuroimaging research in pediatric obsessive-compulsive disorder
title_short Translational neuroimaging research in pediatric obsessive-compulsive disorder
title_sort translational neuroimaging research in pediatric obsessive-compulsive disorder
topic Translational Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181954/
https://www.ncbi.nlm.nih.gov/pubmed/20623921
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