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Drug treatment of obsessive-compulsive disorder

Knowledge of pharmacotherapeutic treatment options in obsessive-compulsive disorder (OCD) has grown considerably over the past 40 years. Serotonergic antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and clomipramine, are the established pharmacologic first-line treatment of O...

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Autor principal: Kellner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181958/
https://www.ncbi.nlm.nih.gov/pubmed/20623923
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author Kellner, Michael
author_facet Kellner, Michael
author_sort Kellner, Michael
collection PubMed
description Knowledge of pharmacotherapeutic treatment options in obsessive-compulsive disorder (OCD) has grown considerably over the past 40 years. Serotonergic antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and clomipramine, are the established pharmacologic first-line treatment of OCD. Medium to large dosages and acute treatment for at least 3 months are recommended until efficacy is assessed. In case of significant improvement, maintenance treatment is necessary. Unfortunately, about half of the patients do not respond sufficiently to oral serotonergic antidepressants; augmentation with atypical antipsychotics is an established second-line drug treatment strategy. Alternatives include intravenous serotonergic antidepressants and combination with or switch to cognitive behavioral psychotherapy. Remarkably, a considerable proportion of OCD patients still do not receive rational drug treatment. Novel research approaches, such as preliminary treatment studies with glutamatergic substances, and trials with further drugs, as well as needed aspects of future research, are reviewed.
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spelling pubmed-31819582011-10-27 Drug treatment of obsessive-compulsive disorder Kellner, Michael Dialogues Clin Neurosci Clinical Research Knowledge of pharmacotherapeutic treatment options in obsessive-compulsive disorder (OCD) has grown considerably over the past 40 years. Serotonergic antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and clomipramine, are the established pharmacologic first-line treatment of OCD. Medium to large dosages and acute treatment for at least 3 months are recommended until efficacy is assessed. In case of significant improvement, maintenance treatment is necessary. Unfortunately, about half of the patients do not respond sufficiently to oral serotonergic antidepressants; augmentation with atypical antipsychotics is an established second-line drug treatment strategy. Alternatives include intravenous serotonergic antidepressants and combination with or switch to cognitive behavioral psychotherapy. Remarkably, a considerable proportion of OCD patients still do not receive rational drug treatment. Novel research approaches, such as preliminary treatment studies with glutamatergic substances, and trials with further drugs, as well as needed aspects of future research, are reviewed. Les Laboratoires Servier 2010-06 /pmc/articles/PMC3181958/ /pubmed/20623923 Text en Copyright: © 2010 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research
Kellner, Michael
Drug treatment of obsessive-compulsive disorder
title Drug treatment of obsessive-compulsive disorder
title_full Drug treatment of obsessive-compulsive disorder
title_fullStr Drug treatment of obsessive-compulsive disorder
title_full_unstemmed Drug treatment of obsessive-compulsive disorder
title_short Drug treatment of obsessive-compulsive disorder
title_sort drug treatment of obsessive-compulsive disorder
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181958/
https://www.ncbi.nlm.nih.gov/pubmed/20623923
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