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New insights into perinatal depression: pathogenesis and treatment during pregnancy and postpartum

Maternal perinatal mental health has enormous consequences for the well-being of the mother, her baby, and the family. Although it is well documented that perinatal depression is both common and morbid, with a prevalence of 10% to 15% in the general population, there remain many critically important...

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Autor principal: Meltzer-Brody, Samantha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181972/
https://www.ncbi.nlm.nih.gov/pubmed/21485749
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author Meltzer-Brody, Samantha
author_facet Meltzer-Brody, Samantha
author_sort Meltzer-Brody, Samantha
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description Maternal perinatal mental health has enormous consequences for the well-being of the mother, her baby, and the family. Although it is well documented that perinatal depression is both common and morbid, with a prevalence of 10% to 15% in the general population, there remain many critically important unanswered questions about the pathogenesis of perinatal depression and most effective treatment regimens. Current lines of evidence from both human and animal models implicate hormonal dysregulation, abnormalities in hypothalamic-pituitary-adrenal axis activity, and the contributions of genetics and epigenetics as playing key roles in the development of perinatal reproductive mood disorders. Investigations into both human and animal models of perinatal depression offer much promise for the future identification of the underlying pathophysiology and subsequent early identification and/or prevention and appropriate treatment for women at risk for postpartum depression. Lastly, although it is generally accepted that pregnancy is not protective with regard to new onset or relapse of depression, the way to best treat maternal depression during pregnancy and lactation remains hotly debated. Future research in this area will more clearly elucidate the underlying pathogenesis, the potential long-term impact of perinatal depression on the developing fetus, and how best to counsel pregnant women about the risks of untreated major depressive disorder versus the risks of psychopharmacologic treatment during pregnancy and lactation.
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spelling pubmed-31819722011-10-27 New insights into perinatal depression: pathogenesis and treatment during pregnancy and postpartum Meltzer-Brody, Samantha Dialogues Clin Neurosci Clinical Research Maternal perinatal mental health has enormous consequences for the well-being of the mother, her baby, and the family. Although it is well documented that perinatal depression is both common and morbid, with a prevalence of 10% to 15% in the general population, there remain many critically important unanswered questions about the pathogenesis of perinatal depression and most effective treatment regimens. Current lines of evidence from both human and animal models implicate hormonal dysregulation, abnormalities in hypothalamic-pituitary-adrenal axis activity, and the contributions of genetics and epigenetics as playing key roles in the development of perinatal reproductive mood disorders. Investigations into both human and animal models of perinatal depression offer much promise for the future identification of the underlying pathophysiology and subsequent early identification and/or prevention and appropriate treatment for women at risk for postpartum depression. Lastly, although it is generally accepted that pregnancy is not protective with regard to new onset or relapse of depression, the way to best treat maternal depression during pregnancy and lactation remains hotly debated. Future research in this area will more clearly elucidate the underlying pathogenesis, the potential long-term impact of perinatal depression on the developing fetus, and how best to counsel pregnant women about the risks of untreated major depressive disorder versus the risks of psychopharmacologic treatment during pregnancy and lactation. Les Laboratoires Servier 2011-03 /pmc/articles/PMC3181972/ /pubmed/21485749 Text en Copyright: © 2011 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research
Meltzer-Brody, Samantha
New insights into perinatal depression: pathogenesis and treatment during pregnancy and postpartum
title New insights into perinatal depression: pathogenesis and treatment during pregnancy and postpartum
title_full New insights into perinatal depression: pathogenesis and treatment during pregnancy and postpartum
title_fullStr New insights into perinatal depression: pathogenesis and treatment during pregnancy and postpartum
title_full_unstemmed New insights into perinatal depression: pathogenesis and treatment during pregnancy and postpartum
title_short New insights into perinatal depression: pathogenesis and treatment during pregnancy and postpartum
title_sort new insights into perinatal depression: pathogenesis and treatment during pregnancy and postpartum
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181972/
https://www.ncbi.nlm.nih.gov/pubmed/21485749
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