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Cognitive training in schizophrenia: a neuroscience-based approach

Meta-analytic data from over a decade of research in cognitive remediation, when combined with recent findings from basic and clinical neuroscience, have resulted in a new understanding of the critical elements that can contribute to successful cognitive training approaches for schizophrenia. Some o...

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Autores principales: Genevsky, Alexander, Garrett, Coleman T., Alexander, Phillip P., Vinogradov, Sophia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181983/
https://www.ncbi.nlm.nih.gov/pubmed/20954435
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author Genevsky, Alexander
Garrett, Coleman T.
Alexander, Phillip P.
Vinogradov, Sophia
author_facet Genevsky, Alexander
Garrett, Coleman T.
Alexander, Phillip P.
Vinogradov, Sophia
author_sort Genevsky, Alexander
collection PubMed
description Meta-analytic data from over a decade of research in cognitive remediation, when combined with recent findings from basic and clinical neuroscience, have resulted in a new understanding of the critical elements that can contribute to successful cognitive training approaches for schizophrenia. Some of these elements include: the use of computerized repetitive practice methods, high dosing schedules, a focus on sensory processing, and carefully constrained and individually adapted learning trials. In a preliminary randomized controlled trial of cognitive training exercises based on these principles, we demonstrated significant improvements in working memory, verbal learning and memory, and global cognition in patients with schizophrenia. These cognitive improvements were accompanied by neurobiological findings suggestive of learning-induced cortical plasticity. Future directions for research and essential remaining questions are discussed.
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spelling pubmed-31819832011-10-27 Cognitive training in schizophrenia: a neuroscience-based approach Genevsky, Alexander Garrett, Coleman T. Alexander, Phillip P. Vinogradov, Sophia Dialogues Clin Neurosci Brief Report Meta-analytic data from over a decade of research in cognitive remediation, when combined with recent findings from basic and clinical neuroscience, have resulted in a new understanding of the critical elements that can contribute to successful cognitive training approaches for schizophrenia. Some of these elements include: the use of computerized repetitive practice methods, high dosing schedules, a focus on sensory processing, and carefully constrained and individually adapted learning trials. In a preliminary randomized controlled trial of cognitive training exercises based on these principles, we demonstrated significant improvements in working memory, verbal learning and memory, and global cognition in patients with schizophrenia. These cognitive improvements were accompanied by neurobiological findings suggestive of learning-induced cortical plasticity. Future directions for research and essential remaining questions are discussed. Les Laboratoires Servier 2010-09 /pmc/articles/PMC3181983/ /pubmed/20954435 Text en Copyright: © 2010 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Genevsky, Alexander
Garrett, Coleman T.
Alexander, Phillip P.
Vinogradov, Sophia
Cognitive training in schizophrenia: a neuroscience-based approach
title Cognitive training in schizophrenia: a neuroscience-based approach
title_full Cognitive training in schizophrenia: a neuroscience-based approach
title_fullStr Cognitive training in schizophrenia: a neuroscience-based approach
title_full_unstemmed Cognitive training in schizophrenia: a neuroscience-based approach
title_short Cognitive training in schizophrenia: a neuroscience-based approach
title_sort cognitive training in schizophrenia: a neuroscience-based approach
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181983/
https://www.ncbi.nlm.nih.gov/pubmed/20954435
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