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A pragmatic view on pragmatic trials
Clinical trials have been the main tool used by the health sciences community to test and evaluate interventions. Trials can fall into two broad categories: pragmatic and explanatory. Pragmatic trials are designed to evaluate the effectiveness of interventions in real-life routine practice condition...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Les Laboratoires Servier
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181997/ https://www.ncbi.nlm.nih.gov/pubmed/21842619 |
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author | Patsopoulos, Nikolaos A. |
author_facet | Patsopoulos, Nikolaos A. |
author_sort | Patsopoulos, Nikolaos A. |
collection | PubMed |
description | Clinical trials have been the main tool used by the health sciences community to test and evaluate interventions. Trials can fall into two broad categories: pragmatic and explanatory. Pragmatic trials are designed to evaluate the effectiveness of interventions in real-life routine practice conditions, whereas explanatory trials aim to test whether an intervention works under optimal situations. Pragmatic trials produce results that can be generalized and applied in routine practice settings. Since most results from exploratory trials fail to be broadly generalizable, the “pragmatic design” has gained momentum. This review describes the concept of pragmatism, and explains in particular that there is a continuum between pragmatic and explanatory trials, rather than a dichotomy. Special focus is put on the limitations of the pragmatic trials, while recognizing the importance for and impact of this design on medical practice. |
format | Online Article Text |
id | pubmed-3181997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Les Laboratoires Servier |
record_format | MEDLINE/PubMed |
spelling | pubmed-31819972011-10-27 A pragmatic view on pragmatic trials Patsopoulos, Nikolaos A. Dialogues Clin Neurosci Clinical Research Clinical trials have been the main tool used by the health sciences community to test and evaluate interventions. Trials can fall into two broad categories: pragmatic and explanatory. Pragmatic trials are designed to evaluate the effectiveness of interventions in real-life routine practice conditions, whereas explanatory trials aim to test whether an intervention works under optimal situations. Pragmatic trials produce results that can be generalized and applied in routine practice settings. Since most results from exploratory trials fail to be broadly generalizable, the “pragmatic design” has gained momentum. This review describes the concept of pragmatism, and explains in particular that there is a continuum between pragmatic and explanatory trials, rather than a dichotomy. Special focus is put on the limitations of the pragmatic trials, while recognizing the importance for and impact of this design on medical practice. Les Laboratoires Servier 2011-06 /pmc/articles/PMC3181997/ /pubmed/21842619 Text en Copyright: © 2011 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Research Patsopoulos, Nikolaos A. A pragmatic view on pragmatic trials |
title | A pragmatic view on pragmatic trials |
title_full | A pragmatic view on pragmatic trials |
title_fullStr | A pragmatic view on pragmatic trials |
title_full_unstemmed | A pragmatic view on pragmatic trials |
title_short | A pragmatic view on pragmatic trials |
title_sort | pragmatic view on pragmatic trials |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181997/ https://www.ncbi.nlm.nih.gov/pubmed/21842619 |
work_keys_str_mv | AT patsopoulosnikolaosa apragmaticviewonpragmatictrials AT patsopoulosnikolaosa pragmaticviewonpragmatictrials |