Cargando…
Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think
Notch signaling is often considered a model hematopoietic proto-oncogene because of its role as the main trigger of T cell acute lymphoblastic leukemia (T-ALL). Although its role in T-ALL is well characterized and further supported by a high frequency of activating NOTCH1 mutations in T-ALL patients...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182047/ https://www.ncbi.nlm.nih.gov/pubmed/21948802 http://dx.doi.org/10.1084/jem.20111855 |
_version_ | 1782212861597057024 |
---|---|
author | Lobry, Camille Oh, Philmo Aifantis, Iannis |
author_facet | Lobry, Camille Oh, Philmo Aifantis, Iannis |
author_sort | Lobry, Camille |
collection | PubMed |
description | Notch signaling is often considered a model hematopoietic proto-oncogene because of its role as the main trigger of T cell acute lymphoblastic leukemia (T-ALL). Although its role in T-ALL is well characterized and further supported by a high frequency of activating NOTCH1 mutations in T-ALL patients, it still remains an open question whether the effects of Notch signaling are causative in other types of cancer, including solid tumors. Growing evidence supported by recent studies unexpectedly shows that Notch signaling can also have a potent tumor suppressor function in both solid tumors and hematological malignancies. We discuss the intriguing possibility that the pleiotropic functions of Notch can be tumor suppressive or oncogenic depending on the cellular context. |
format | Online Article Text |
id | pubmed-3182047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-31820472012-03-26 Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think Lobry, Camille Oh, Philmo Aifantis, Iannis J Exp Med Minireview Notch signaling is often considered a model hematopoietic proto-oncogene because of its role as the main trigger of T cell acute lymphoblastic leukemia (T-ALL). Although its role in T-ALL is well characterized and further supported by a high frequency of activating NOTCH1 mutations in T-ALL patients, it still remains an open question whether the effects of Notch signaling are causative in other types of cancer, including solid tumors. Growing evidence supported by recent studies unexpectedly shows that Notch signaling can also have a potent tumor suppressor function in both solid tumors and hematological malignancies. We discuss the intriguing possibility that the pleiotropic functions of Notch can be tumor suppressive or oncogenic depending on the cellular context. The Rockefeller University Press 2011-09-26 /pmc/articles/PMC3182047/ /pubmed/21948802 http://dx.doi.org/10.1084/jem.20111855 Text en © 2011 Lobry et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Minireview Lobry, Camille Oh, Philmo Aifantis, Iannis Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think |
title | Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think |
title_full | Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think |
title_fullStr | Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think |
title_full_unstemmed | Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think |
title_short | Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think |
title_sort | oncogenic and tumor suppressor functions of notch in cancer: it’s notch what you think |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182047/ https://www.ncbi.nlm.nih.gov/pubmed/21948802 http://dx.doi.org/10.1084/jem.20111855 |
work_keys_str_mv | AT lobrycamille oncogenicandtumorsuppressorfunctionsofnotchincanceritsnotchwhatyouthink AT ohphilmo oncogenicandtumorsuppressorfunctionsofnotchincanceritsnotchwhatyouthink AT aifantisiannis oncogenicandtumorsuppressorfunctionsofnotchincanceritsnotchwhatyouthink |