Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

It is believed that megakaryocytes undergo a specialized form of apoptosis to shed platelets. Conversely, a range of pathophysiological insults, including chemotherapy, are thought to cause thrombocytopenia by inducing the apoptotic death of megakaryocytes and their progenitors. To resolve this para...

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Detalles Bibliográficos
Autores principales: Josefsson, Emma C., James, Chloé, Henley, Katya J., Debrincat, Marlyse A., Rogers, Kelly L., Dowling, Mark R., White, Michael J., Kruse, Elizabeth A., Lane, Rachael M., Ellis, Sarah, Nurden, Paquita, Mason, Kylie D., O’Reilly, Lorraine A., Roberts, Andrew W., Metcalf, Donald, Huang, David C.S., Kile, Benjamin T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182050/
https://www.ncbi.nlm.nih.gov/pubmed/21911424
http://dx.doi.org/10.1084/jem.20110750

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