Cargando…

WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity

Patients with the immunodeficiency Wiskott-Aldrich syndrome (WAS) frequently develop systemic autoimmunity. Here, we demonstrate that mutation of the WAS gene results in B cells that are hyperresponsive to B cell receptor and Toll-like receptor (TLR) signals in vitro, thereby promoting a B cell–intr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Becker-Herman, Shirly, Meyer-Bahlburg, Almut, Schwartz, Marc A., Jackson, Shaun W., Hudkins, Kelly L., Liu, Chaohong, Sather, Blythe D., Khim, Socheath, Liggitt, Denny, Song, Wenxia, Silverman, Gregg J., Alpers, Charles E., Rawlings, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182055/ https://www.ncbi.nlm.nih.gov/pubmed/21875954 http://dx.doi.org/10.1084/jem.20110200

Ejemplares similares

B cell–intrinsic TLR signals amplify but are not required for humoral immunity
por: Meyer-Bahlburg, Almut, et al.
Publicado: (2007)

Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis
por: Meyer-Bahlburg, Almut, et al.
Publicado: (2008)

Trypanosoma cruzi trans-sialidase initiates an ROR-γt–AHR-independent program leading to IL-17 production by activated B cells
por: Bermejo, Daniela A, et al.
Publicado: (2013)

Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector
por: Singh, Swati, et al.
Publicado: (2016)

G(αq)-containing G proteins regulate B cell selection and survival and are required to prevent B cell–dependent autoimmunity
por: Misra, Ravi S., et al.
Publicado: (2010)

Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector
por: Seymour, Brenda J., et al.
Publicado: (2021)

N-WASP Is Essential for the Negative Regulation of B Cell Receptor Signaling
por: Liu, Chaohong, et al.
Publicado: (2013)

Pathology identifies glomerular treatment targets in diabetic nephropathy
por: Alpers, Charles E., et al.
Publicado: (2018)

Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome
por: Kolhatkar, Nikita S., et al.
Publicado: (2015)

The A946T variant IFIH1 RNA sensor mediates an interferon program that limits viral infection but increases the risk for autoimmunity
por: Gorman, Jacquelyn A., et al.
Publicado: (2017)

Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation
por: Meyer-Bahlburg, Almut, et al.
Publicado: (2008)

Testing drug combinations to slow aging
por: Ladiges, Warren, et al.
Publicado: (2017)

Variation in intrinsic resistance of pea aphids to parasitoid wasps: A transcriptomic basis
por: McLean, Ailsa H. C., et al.
Publicado: (2020)

Investigation into Early Steps of Actin Recognition by the Intrinsically Disordered N-WASP Domain V
por: Chan-Yao-Chong, Maud, et al.
Publicado: (2019)

Alternative Nesting Strategies of Polistine Wasps in a Subtropical Locale
por: Nacko, Scott, et al.
Publicado: (2022)

Reduced Number of Transitional and Naive B Cells in Addition to Decreased BAFF Levels in Response to the T Cell Independent Immunogen Pneumovax(®)23
por: Roth, Alena, et al.
Publicado: (2016)

Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation
por: Wray-Dutra, Michelle N., et al.
Publicado: (2018)

WASp Is Crucial for the Unique Architecture of the Immunological Synapse in Germinal Center B-Cells
por: Li, Yanan, et al.
Publicado: (2021)

Late gestation modulation of fetal glucocorticoid effects requires the receptor for leukemia inhibitory factor: an observational study
por: Ware, Carol B, et al.
Publicado: (2003)

Corrigendum: WASp Is Crucial for the Unique Architecture of the Immunological Synapse in Germinal Center B-Cells
por: Li, Yanan, et al.
Publicado: (2022)

WASp Is Essential for Effector-to-Memory conversion and for Maintenance of CD8(+)T Cell Memory
por: Liu, Qiao, et al.
Publicado: (2019)

Pathology is a critical aspect of preclinical aging studies
por: Ladiges, Warren, et al.
Publicado: (2013)

In Utero Exposure to Diesel Exhaust Air Pollution Promotes Adverse Intrauterine Conditions, Resulting in Weight Gain, Altered Blood Pressure, and Increased Susceptibility to Heart Failure in Adult Mice
por: Weldy, Chad S., et al.
Publicado: (2014)

The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets
por: Gorman, Jacquelyn A., et al.
Publicado: (2019)

The phenotypes of podocytes and parietal epithelial cells may overlap in diabetic nephropathy
por: Andeen, Nicole K., et al.
Publicado: (2015)

WASPs with memory
por: Wells, William A.
Publicado: (2003)

Wasp Sting
por: Watson, John
Publicado: (1905)

Wasps' Nurseries
Publicado: (1893)

Optical microangiography of retina and choroid and measurement of total retinal blood flow in mice
por: Zhi, Zhongwei, et al.
Publicado: (2012)

Instructions for Flow Cytometric Detection of ASC Specks as a Readout of Inflammasome Activation in Human Blood
por: Wittmann, Nico, et al.
Publicado: (2021)

A Preliminary Investigation of the Interactions between the Brood Parasite Chalcoela iphitalis and Its Polistine Wasp Hosts
por: Nacko, Scott, et al.
Publicado: (2017)

WASP family proteins regulate the mobility of the B cell receptor during signaling activation
por: Rey-Suarez, Ivan, et al.
Publicado: (2020)

The wasps : overture ; Serenade to music : (orchestral version) /
por: Vaughan Williams, Ralph, 1872-1958
Publicado: (1984)

Intrinsically disordered proteins play diverse roles in cell signaling
por: Bondos, Sarah E., et al.
Publicado: (2022)

Wasp sting of the cornea
por: Muto, Tetsuya, et al.
Publicado: (2018)

Don’t Kill the WASP!
por: Tesio, Melania
Publicado: (2019)

Modern Wasp Waists
Publicado: (1892)

A Pathogenic Role for Myelin-Specific Cd8(+) T Cells in a Model for Multiple Sclerosis
por: Huseby, Eric S., et al.
Publicado: (2001)

Toll‐like receptor 2 has a prominent but nonessential role in innate immunity to Staphylococcus aureus pneumonia
por: Skerrett, Shawn J., et al.
Publicado: (2017)

N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters
por: Bhanja, Anshuman, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_1ursk9rbferepq43bhqikrgmtf