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Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice

Bisphenol A (BPA) is a man-made compound used to make polycarbonate plastics and epoxy resins; public health concerns have been fueled by findings that BPA exposure can reduce sex differences in brain and some behaviors. We asked if a low BPA dose, within the range measured in humans, ingested durin...

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Autores principales: Wolstenholme, Jennifer T., Taylor, Julia A., Shetty, Savera R. J., Edwards, Michelle, Connelly, Jessica J., Rissman, Emilie F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182223/
https://www.ncbi.nlm.nih.gov/pubmed/21980460
http://dx.doi.org/10.1371/journal.pone.0025448
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author Wolstenholme, Jennifer T.
Taylor, Julia A.
Shetty, Savera R. J.
Edwards, Michelle
Connelly, Jessica J.
Rissman, Emilie F.
author_facet Wolstenholme, Jennifer T.
Taylor, Julia A.
Shetty, Savera R. J.
Edwards, Michelle
Connelly, Jessica J.
Rissman, Emilie F.
author_sort Wolstenholme, Jennifer T.
collection PubMed
description Bisphenol A (BPA) is a man-made compound used to make polycarbonate plastics and epoxy resins; public health concerns have been fueled by findings that BPA exposure can reduce sex differences in brain and some behaviors. We asked if a low BPA dose, within the range measured in humans, ingested during pregnancy, would affect social behaviors in prepubertal mice. We noted sex differences in social interactions whereby females spent more time sitting side-by-side, while males engaged in more exploring and sitting alone. In addition BPA increased display of nose-to-nose contacts, play solicitations and approaches in both sexes. Interactions between sex and diet were found for self grooming, social interactions while sitting side-by-side and following the other mouse. In all these cases interactions were produced by differences between control and BPA females. We examined brains from embryos during late gestation to determine if gene expression differences might be correlated with some of the sexually dimorphic or BPA affected behaviors we observed. Because BPA treatments ended at birth we took the brains during embryogenesis to increase the probability of discovering BPA mediated effects. We also selected this embryonic age (E18.5) because it coincides with the onset of sexual differentiation of the brain. Interestingly, mRNA for the glutamate transporter, Slc1a1, was enhanced by exposure to BPA in female brains. Also we noted that BPA changed the expression of two of the three DNA methyltransferase genes, Dnmt1 and Dnmt3a. We propose that BPA affects DNA methylation of Sc1a1 during neural development. Sex differences in juvenile social interactions are affected by BPA and in particular this compound modifies behavior in females.
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spelling pubmed-31822232011-10-06 Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice Wolstenholme, Jennifer T. Taylor, Julia A. Shetty, Savera R. J. Edwards, Michelle Connelly, Jessica J. Rissman, Emilie F. PLoS One Research Article Bisphenol A (BPA) is a man-made compound used to make polycarbonate plastics and epoxy resins; public health concerns have been fueled by findings that BPA exposure can reduce sex differences in brain and some behaviors. We asked if a low BPA dose, within the range measured in humans, ingested during pregnancy, would affect social behaviors in prepubertal mice. We noted sex differences in social interactions whereby females spent more time sitting side-by-side, while males engaged in more exploring and sitting alone. In addition BPA increased display of nose-to-nose contacts, play solicitations and approaches in both sexes. Interactions between sex and diet were found for self grooming, social interactions while sitting side-by-side and following the other mouse. In all these cases interactions were produced by differences between control and BPA females. We examined brains from embryos during late gestation to determine if gene expression differences might be correlated with some of the sexually dimorphic or BPA affected behaviors we observed. Because BPA treatments ended at birth we took the brains during embryogenesis to increase the probability of discovering BPA mediated effects. We also selected this embryonic age (E18.5) because it coincides with the onset of sexual differentiation of the brain. Interestingly, mRNA for the glutamate transporter, Slc1a1, was enhanced by exposure to BPA in female brains. Also we noted that BPA changed the expression of two of the three DNA methyltransferase genes, Dnmt1 and Dnmt3a. We propose that BPA affects DNA methylation of Sc1a1 during neural development. Sex differences in juvenile social interactions are affected by BPA and in particular this compound modifies behavior in females. Public Library of Science 2011-09-28 /pmc/articles/PMC3182223/ /pubmed/21980460 http://dx.doi.org/10.1371/journal.pone.0025448 Text en Wolstenholme et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wolstenholme, Jennifer T.
Taylor, Julia A.
Shetty, Savera R. J.
Edwards, Michelle
Connelly, Jessica J.
Rissman, Emilie F.
Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice
title Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice
title_full Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice
title_fullStr Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice
title_full_unstemmed Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice
title_short Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice
title_sort gestational exposure to low dose bisphenol a alters social behavior in juvenile mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182223/
https://www.ncbi.nlm.nih.gov/pubmed/21980460
http://dx.doi.org/10.1371/journal.pone.0025448
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