Novel Nucleotide and Amino Acid Covariation between the 5′UTR and the NS2/NS3 Proteins of Hepatitis C Virus: Bioinformatic and Functional Analyses

Molecular covariation of highly polymorphic viruses is thought to have crucial effects on viral replication and fitness. This study employs association rule data mining of hepatitis C virus (HCV) sequences to search for specific evolutionary covariation and then tests functional relevance on HCV rep...

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Detalles Bibliográficos
Autores principales: Sun, Hung-Yu, Ou, Nai-Ying, Wang, Shainn-Wei, Liu, Wen-Chun, Cheng, Ting-Fang, Shr, Shiou-Jiuan, Sun, Koun-Tem, Chang, Ting-Tsung, Young, Kung-Chia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182228/
https://www.ncbi.nlm.nih.gov/pubmed/21980483
http://dx.doi.org/10.1371/journal.pone.0025530

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