Peripheral CLOCK Regulates Target-Tissue Glucocorticoid Receptor Transcriptional Activity in a Circadian Fashion in Man

CONTEXT AND OBJECTIVE: Circulating cortisol fluctuates diurnally under the control of the “master” circadian CLOCK, while the peripheral “slave” counterpart of the latter regulates the transcriptional activity of the glucocorticoid receptor (GR) at local glucocorticoid target tissues through acetyla...

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Detalles Bibliográficos
Autores principales: Charmandari, Evangelia, Chrousos, George P., Lambrou, George I., Pavlaki, Aikaterini, Koide, Hisashi, Ng, Sinnie Sin Man, Kino, Tomoshige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182238/
https://www.ncbi.nlm.nih.gov/pubmed/21980503
http://dx.doi.org/10.1371/journal.pone.0025612

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