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GSTP1 DNA Methylation and Expression Status Is Indicative of 5-aza-2′-Deoxycytidine Efficacy in Human Prostate Cancer Cells

DNA methylation plays an important role in carcinogenesis and the reversibility of this epigenetic modification makes it a potential therapeutic target. To date, DNA methyltransferase inhibitors (DNMTi) have not demonstrated clinical efficacy in prostate cancer, with one of the major obstacles being...

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Detalles Bibliográficos
Autores principales:	Chiam, Karen, Centenera, Margaret M., Butler, Lisa M., Tilley, Wayne D., Bianco-Miotto, Tina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182253/ https://www.ncbi.nlm.nih.gov/pubmed/21980513 http://dx.doi.org/10.1371/journal.pone.0025634

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