High cut-off haemodialysis induces remission of recurrent idiopathic focal segmental glomerulosclerosis after renal transplantation but is no alternative to plasmapheresis

A 26-year-old male experienced a recurrence of idiopathic focal segmental glomerulosclerosis (iFSGS) after his second renal transplant. Reduction of proteinuria was rapidly induced by plasmapheresis (PP) and the patient has remained in remission with a once-weekly PP regimen, which has now been cont...

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Autores principales: Noorlander, Iris, Hesselink, Dennis A., Wabbijn, Marike, Betjes, Michiel G. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
II. Clinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182260/
https://www.ncbi.nlm.nih.gov/pubmed/21969845
http://dx.doi.org/10.1093/ndtplus/sfr084
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author Noorlander, Iris
Hesselink, Dennis A.
Wabbijn, Marike
Betjes, Michiel G. H.
author_facet Noorlander, Iris
Hesselink, Dennis A.
Wabbijn, Marike
Betjes, Michiel G. H.
author_sort Noorlander, Iris
collection PubMed
description A 26-year-old male experienced a recurrence of idiopathic focal segmental glomerulosclerosis (iFSGS) after his second renal transplant. Reduction of proteinuria was rapidly induced by plasmapheresis (PP) and the patient has remained in remission with a once-weekly PP regimen, which has now been continued for >3½ years. We were also able to induce remission of iFSGS in this patient by treatment with high cut-off haemodialysis using the Theralite™ dialyser. This observation lends support for the pathophysiological role of an as yet unknown, circulating glomerular filtration barrier permeability factor with an estimated weight of between 30 and 50 kDa.
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spelling pubmed-31822602011-10-03 High cut-off haemodialysis induces remission of recurrent idiopathic focal segmental glomerulosclerosis after renal transplantation but is no alternative to plasmapheresis Noorlander, Iris Hesselink, Dennis A. Wabbijn, Marike Betjes, Michiel G. H. NDT Plus II. Clinical Reports A 26-year-old male experienced a recurrence of idiopathic focal segmental glomerulosclerosis (iFSGS) after his second renal transplant. Reduction of proteinuria was rapidly induced by plasmapheresis (PP) and the patient has remained in remission with a once-weekly PP regimen, which has now been continued for >3½ years. We were also able to induce remission of iFSGS in this patient by treatment with high cut-off haemodialysis using the Theralite™ dialyser. This observation lends support for the pathophysiological role of an as yet unknown, circulating glomerular filtration barrier permeability factor with an estimated weight of between 30 and 50 kDa. Oxford University Press 2011-10 2011-07-26 /pmc/articles/PMC3182260/ /pubmed/21969845 http://dx.doi.org/10.1093/ndtplus/sfr084 Text en © The Author 2011. Published by Oxford University Press [on behalf of ERA-EDTA]. http://creativecommons.org/licenses/by-nc/2.5/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle II. Clinical Reports
Noorlander, Iris
Hesselink, Dennis A.
Wabbijn, Marike
Betjes, Michiel G. H.
High cut-off haemodialysis induces remission of recurrent idiopathic focal segmental glomerulosclerosis after renal transplantation but is no alternative to plasmapheresis
title High cut-off haemodialysis induces remission of recurrent idiopathic focal segmental glomerulosclerosis after renal transplantation but is no alternative to plasmapheresis
title_full High cut-off haemodialysis induces remission of recurrent idiopathic focal segmental glomerulosclerosis after renal transplantation but is no alternative to plasmapheresis
title_fullStr High cut-off haemodialysis induces remission of recurrent idiopathic focal segmental glomerulosclerosis after renal transplantation but is no alternative to plasmapheresis
title_full_unstemmed High cut-off haemodialysis induces remission of recurrent idiopathic focal segmental glomerulosclerosis after renal transplantation but is no alternative to plasmapheresis
title_short High cut-off haemodialysis induces remission of recurrent idiopathic focal segmental glomerulosclerosis after renal transplantation but is no alternative to plasmapheresis
title_sort high cut-off haemodialysis induces remission of recurrent idiopathic focal segmental glomerulosclerosis after renal transplantation but is no alternative to plasmapheresis
topic II. Clinical Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182260/
https://www.ncbi.nlm.nih.gov/pubmed/21969845
http://dx.doi.org/10.1093/ndtplus/sfr084
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