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Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax
Cutaneous anthrax outbreaks occurred in Bangladesh from August to October 2009. As part of the epidemiological response and to confirm anthrax diagnoses, serum samples were collected from suspected case patients with observed cutaneous lesions. Anthrax lethal factor (LF), anti-protective antigen (an...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Oxford University Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182309/ https://www.ncbi.nlm.nih.gov/pubmed/21908727 http://dx.doi.org/10.1093/infdis/jir543 |
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author | Boyer, Anne E. Quinn, Conrad P. Beesley, Cari A. Gallegos-Candela, Maribel Marston, Chung K. Cronin, Li X. Lins, Renato C. Stoddard, Robyn A. Li, Han Schiffer, Jarad Hossain, M. Jahangir Chakraborty, Apurba Rahman, Mahmudur Luby, Stephen P. Shieh, Wun-Ju Zaki, Sherif Barr, John R. Hoffmaster, Alex R. |
author_facet | Boyer, Anne E. Quinn, Conrad P. Beesley, Cari A. Gallegos-Candela, Maribel Marston, Chung K. Cronin, Li X. Lins, Renato C. Stoddard, Robyn A. Li, Han Schiffer, Jarad Hossain, M. Jahangir Chakraborty, Apurba Rahman, Mahmudur Luby, Stephen P. Shieh, Wun-Ju Zaki, Sherif Barr, John R. Hoffmaster, Alex R. |
author_sort | Boyer, Anne E. |
collection | PubMed |
description | Cutaneous anthrax outbreaks occurred in Bangladesh from August to October 2009. As part of the epidemiological response and to confirm anthrax diagnoses, serum samples were collected from suspected case patients with observed cutaneous lesions. Anthrax lethal factor (LF), anti-protective antigen (anti-PA) immunoglobulin G (IgG), and anthrax lethal toxin neutralization activity (TNA) levels were determined in acute and convalescent serum of 26 case patients with suspected cutaneous anthrax from the first and largest of these outbreaks. LF (0.005–1.264 ng/mL) was detected in acute serum from 18 of 26 individuals. Anti-PA IgG and TNA were detected in sera from the same 18 individuals and ranged from 10.0 to 679.5 μg/mL and 27 to 593 units, respectively. Seroconversion to serum anti-PA and TNA was found only in case patients with measurable toxemia. This is the first report of quantitative analysis of serum LF in cutaneous anthrax and the first to associate acute stage toxemia with subsequent antitoxin antibody responses. |
format | Online Article Text |
id | pubmed-3182309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-31823092011-11-01 Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax Boyer, Anne E. Quinn, Conrad P. Beesley, Cari A. Gallegos-Candela, Maribel Marston, Chung K. Cronin, Li X. Lins, Renato C. Stoddard, Robyn A. Li, Han Schiffer, Jarad Hossain, M. Jahangir Chakraborty, Apurba Rahman, Mahmudur Luby, Stephen P. Shieh, Wun-Ju Zaki, Sherif Barr, John R. Hoffmaster, Alex R. J Infect Dis Major Articles and Brief Reports Cutaneous anthrax outbreaks occurred in Bangladesh from August to October 2009. As part of the epidemiological response and to confirm anthrax diagnoses, serum samples were collected from suspected case patients with observed cutaneous lesions. Anthrax lethal factor (LF), anti-protective antigen (anti-PA) immunoglobulin G (IgG), and anthrax lethal toxin neutralization activity (TNA) levels were determined in acute and convalescent serum of 26 case patients with suspected cutaneous anthrax from the first and largest of these outbreaks. LF (0.005–1.264 ng/mL) was detected in acute serum from 18 of 26 individuals. Anti-PA IgG and TNA were detected in sera from the same 18 individuals and ranged from 10.0 to 679.5 μg/mL and 27 to 593 units, respectively. Seroconversion to serum anti-PA and TNA was found only in case patients with measurable toxemia. This is the first report of quantitative analysis of serum LF in cutaneous anthrax and the first to associate acute stage toxemia with subsequent antitoxin antibody responses. Oxford University Press 2011-11-01 /pmc/articles/PMC3182309/ /pubmed/21908727 http://dx.doi.org/10.1093/infdis/jir543 Text en Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2011. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Major Articles and Brief Reports Boyer, Anne E. Quinn, Conrad P. Beesley, Cari A. Gallegos-Candela, Maribel Marston, Chung K. Cronin, Li X. Lins, Renato C. Stoddard, Robyn A. Li, Han Schiffer, Jarad Hossain, M. Jahangir Chakraborty, Apurba Rahman, Mahmudur Luby, Stephen P. Shieh, Wun-Ju Zaki, Sherif Barr, John R. Hoffmaster, Alex R. Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax |
title | Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax |
title_full | Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax |
title_fullStr | Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax |
title_full_unstemmed | Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax |
title_short | Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax |
title_sort | lethal factor toxemia and anti-protective antigen antibody activity in naturally acquired cutaneous anthrax |
topic | Major Articles and Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182309/ https://www.ncbi.nlm.nih.gov/pubmed/21908727 http://dx.doi.org/10.1093/infdis/jir543 |
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