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Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax

Cutaneous anthrax outbreaks occurred in Bangladesh from August to October 2009. As part of the epidemiological response and to confirm anthrax diagnoses, serum samples were collected from suspected case patients with observed cutaneous lesions. Anthrax lethal factor (LF), anti-protective antigen (an...

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Autores principales: Boyer, Anne E., Quinn, Conrad P., Beesley, Cari A., Gallegos-Candela, Maribel, Marston, Chung K., Cronin, Li X., Lins, Renato C., Stoddard, Robyn A., Li, Han, Schiffer, Jarad, Hossain, M. Jahangir, Chakraborty, Apurba, Rahman, Mahmudur, Luby, Stephen P., Shieh, Wun-Ju, Zaki, Sherif, Barr, John R., Hoffmaster, Alex R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182309/
https://www.ncbi.nlm.nih.gov/pubmed/21908727
http://dx.doi.org/10.1093/infdis/jir543
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author Boyer, Anne E.
Quinn, Conrad P.
Beesley, Cari A.
Gallegos-Candela, Maribel
Marston, Chung K.
Cronin, Li X.
Lins, Renato C.
Stoddard, Robyn A.
Li, Han
Schiffer, Jarad
Hossain, M. Jahangir
Chakraborty, Apurba
Rahman, Mahmudur
Luby, Stephen P.
Shieh, Wun-Ju
Zaki, Sherif
Barr, John R.
Hoffmaster, Alex R.
author_facet Boyer, Anne E.
Quinn, Conrad P.
Beesley, Cari A.
Gallegos-Candela, Maribel
Marston, Chung K.
Cronin, Li X.
Lins, Renato C.
Stoddard, Robyn A.
Li, Han
Schiffer, Jarad
Hossain, M. Jahangir
Chakraborty, Apurba
Rahman, Mahmudur
Luby, Stephen P.
Shieh, Wun-Ju
Zaki, Sherif
Barr, John R.
Hoffmaster, Alex R.
author_sort Boyer, Anne E.
collection PubMed
description Cutaneous anthrax outbreaks occurred in Bangladesh from August to October 2009. As part of the epidemiological response and to confirm anthrax diagnoses, serum samples were collected from suspected case patients with observed cutaneous lesions. Anthrax lethal factor (LF), anti-protective antigen (anti-PA) immunoglobulin G (IgG), and anthrax lethal toxin neutralization activity (TNA) levels were determined in acute and convalescent serum of 26 case patients with suspected cutaneous anthrax from the first and largest of these outbreaks. LF (0.005–1.264 ng/mL) was detected in acute serum from 18 of 26 individuals. Anti-PA IgG and TNA were detected in sera from the same 18 individuals and ranged from 10.0 to 679.5 μg/mL and 27 to 593 units, respectively. Seroconversion to serum anti-PA and TNA was found only in case patients with measurable toxemia. This is the first report of quantitative analysis of serum LF in cutaneous anthrax and the first to associate acute stage toxemia with subsequent antitoxin antibody responses.
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spelling pubmed-31823092011-11-01 Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax Boyer, Anne E. Quinn, Conrad P. Beesley, Cari A. Gallegos-Candela, Maribel Marston, Chung K. Cronin, Li X. Lins, Renato C. Stoddard, Robyn A. Li, Han Schiffer, Jarad Hossain, M. Jahangir Chakraborty, Apurba Rahman, Mahmudur Luby, Stephen P. Shieh, Wun-Ju Zaki, Sherif Barr, John R. Hoffmaster, Alex R. J Infect Dis Major Articles and Brief Reports Cutaneous anthrax outbreaks occurred in Bangladesh from August to October 2009. As part of the epidemiological response and to confirm anthrax diagnoses, serum samples were collected from suspected case patients with observed cutaneous lesions. Anthrax lethal factor (LF), anti-protective antigen (anti-PA) immunoglobulin G (IgG), and anthrax lethal toxin neutralization activity (TNA) levels were determined in acute and convalescent serum of 26 case patients with suspected cutaneous anthrax from the first and largest of these outbreaks. LF (0.005–1.264 ng/mL) was detected in acute serum from 18 of 26 individuals. Anti-PA IgG and TNA were detected in sera from the same 18 individuals and ranged from 10.0 to 679.5 μg/mL and 27 to 593 units, respectively. Seroconversion to serum anti-PA and TNA was found only in case patients with measurable toxemia. This is the first report of quantitative analysis of serum LF in cutaneous anthrax and the first to associate acute stage toxemia with subsequent antitoxin antibody responses. Oxford University Press 2011-11-01 /pmc/articles/PMC3182309/ /pubmed/21908727 http://dx.doi.org/10.1093/infdis/jir543 Text en Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2011. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Boyer, Anne E.
Quinn, Conrad P.
Beesley, Cari A.
Gallegos-Candela, Maribel
Marston, Chung K.
Cronin, Li X.
Lins, Renato C.
Stoddard, Robyn A.
Li, Han
Schiffer, Jarad
Hossain, M. Jahangir
Chakraborty, Apurba
Rahman, Mahmudur
Luby, Stephen P.
Shieh, Wun-Ju
Zaki, Sherif
Barr, John R.
Hoffmaster, Alex R.
Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax
title Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax
title_full Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax
title_fullStr Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax
title_full_unstemmed Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax
title_short Lethal Factor Toxemia and Anti-Protective Antigen Antibody Activity in Naturally Acquired Cutaneous Anthrax
title_sort lethal factor toxemia and anti-protective antigen antibody activity in naturally acquired cutaneous anthrax
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182309/
https://www.ncbi.nlm.nih.gov/pubmed/21908727
http://dx.doi.org/10.1093/infdis/jir543
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