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Reproductive Benefit of Oxidative Damage: An Oxidative Stress “Malevolence”?

High levels of reactive oxygen species (ROS) compared to antioxidant defenses are considered to play a major role in diverse chronic age-related diseases and aging. Here we present an attempt to synthesize information about proximate oxidative processes in aging (relevant to free radical or oxidativ...

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Detalles Bibliográficos
Autores principales: Poljsak, B., Milisav, I., Lampe, T., Ostan, I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182373/
https://www.ncbi.nlm.nih.gov/pubmed/21969876
http://dx.doi.org/10.1155/2011/760978
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author Poljsak, B.
Milisav, I.
Lampe, T.
Ostan, I.
author_facet Poljsak, B.
Milisav, I.
Lampe, T.
Ostan, I.
author_sort Poljsak, B.
collection PubMed
description High levels of reactive oxygen species (ROS) compared to antioxidant defenses are considered to play a major role in diverse chronic age-related diseases and aging. Here we present an attempt to synthesize information about proximate oxidative processes in aging (relevant to free radical or oxidative damage hypotheses of aging) with an evolutionary scenario (credited here to Dawkins hypotheses) involving tradeoffs between the costs and benefits of oxidative stress to reproducing organisms. Oxidative stress may be considered a biological imperfection; therefore, the Dawkins' theory of imperfect adaptation of beings to environment was applied to the role of oxidative stress in processes like famine and infectious diseases and their consequences at the molecular level such as mutations and cell signaling. Arguments are presented that oxidative damage is not necessarily an evolutionary mistake but may be beneficial for reproduction; this may prevail over its harmfulness to health and longevity in evolution. Thus, Dawkins' principle of biological “malevolence” may be an additional biological paradigm for explaining the consequences of oxidative stress.
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spelling pubmed-31823732011-10-03 Reproductive Benefit of Oxidative Damage: An Oxidative Stress “Malevolence”? Poljsak, B. Milisav, I. Lampe, T. Ostan, I. Oxid Med Cell Longev Review Article High levels of reactive oxygen species (ROS) compared to antioxidant defenses are considered to play a major role in diverse chronic age-related diseases and aging. Here we present an attempt to synthesize information about proximate oxidative processes in aging (relevant to free radical or oxidative damage hypotheses of aging) with an evolutionary scenario (credited here to Dawkins hypotheses) involving tradeoffs between the costs and benefits of oxidative stress to reproducing organisms. Oxidative stress may be considered a biological imperfection; therefore, the Dawkins' theory of imperfect adaptation of beings to environment was applied to the role of oxidative stress in processes like famine and infectious diseases and their consequences at the molecular level such as mutations and cell signaling. Arguments are presented that oxidative damage is not necessarily an evolutionary mistake but may be beneficial for reproduction; this may prevail over its harmfulness to health and longevity in evolution. Thus, Dawkins' principle of biological “malevolence” may be an additional biological paradigm for explaining the consequences of oxidative stress. Hindawi Publishing Corporation 2011 2011-09-28 /pmc/articles/PMC3182373/ /pubmed/21969876 http://dx.doi.org/10.1155/2011/760978 Text en Copyright © 2011 B. Poljsak et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Poljsak, B.
Milisav, I.
Lampe, T.
Ostan, I.
Reproductive Benefit of Oxidative Damage: An Oxidative Stress “Malevolence”?
title Reproductive Benefit of Oxidative Damage: An Oxidative Stress “Malevolence”?
title_full Reproductive Benefit of Oxidative Damage: An Oxidative Stress “Malevolence”?
title_fullStr Reproductive Benefit of Oxidative Damage: An Oxidative Stress “Malevolence”?
title_full_unstemmed Reproductive Benefit of Oxidative Damage: An Oxidative Stress “Malevolence”?
title_short Reproductive Benefit of Oxidative Damage: An Oxidative Stress “Malevolence”?
title_sort reproductive benefit of oxidative damage: an oxidative stress “malevolence”?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182373/
https://www.ncbi.nlm.nih.gov/pubmed/21969876
http://dx.doi.org/10.1155/2011/760978
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