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Selectivity in C-alkylation of dianions of protected 6-methyluridine

A regioselective synthesis of 6-ω-alkenyluridines 3, precursors of potent antiviral and antitumor cyclonucleosides 5, is described. While ω-alkenyl halides do not alkylate 6-lithiouridine, compounds 3 were prepared in a regioselective manner by sequential treatment of 6-methyluridine 2 with LTMP or...

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Detalles Bibliográficos
Autores principales:	Nguyen, Ngoc Hoa, Len, Christophe, Castanet, Anne-Sophie, Mortier, Jacques
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2011
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182432/ https://www.ncbi.nlm.nih.gov/pubmed/21977207 http://dx.doi.org/10.3762/bjoc.7.143

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