Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

The 5′ cap structures of higher eukaryote mRNAs have ribose 2′-O-methylation. Likewise, many viruses that replicate in the cytoplasm of eukaryotes have evolved 2′-O-methyltransferases to autonomously modify their mRNAs. However, a defined biological role for 2′-O-methylation of mRNA remains elusive....

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Detalles Bibliográficos
Autores principales: Züst, Roland, Cervantes-Barragan, Luisa, Habjan, Matthias, Maier, Reinhard, Neuman, Benjamin W, Ziebuhr, John, Szretter, Kristy J, Baker, Susan C, Barchet, Winfried, Diamond, Michael S, Siddell, Stuart G, Ludewig, Burkhard, Thiel, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182538/
https://www.ncbi.nlm.nih.gov/pubmed/21217758
http://dx.doi.org/10.1038/ni.1979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182538/
https://www.ncbi.nlm.nih.gov/pubmed/21217758
http://dx.doi.org/10.1038/ni.1979

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