Ligand binding to distinct states diverts aggregation of an amyloid-forming protein

Although small molecules that modulate amyloid formation in vitro have been identified, significant challenges remain in determining precisely how these species act. Here we describe the identification of rifamycin SV as a potent inhibitor of β(2)m fibrillogenesis when added during the lag time of a...

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Detalles Bibliográficos
Autores principales: Woods, Lucy A., Platt, Geoffrey W., Hellewell, Andrew L., Hewitt, Eric W., Homans, Steve W., Ashcroft, Alison E., Radford, Sheena E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182555/
https://www.ncbi.nlm.nih.gov/pubmed/21873994
http://dx.doi.org/10.1038/nchembio.635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182555/
https://www.ncbi.nlm.nih.gov/pubmed/21873994
http://dx.doi.org/10.1038/nchembio.635

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