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Ligand binding to distinct states diverts aggregation of an amyloid-forming protein
Although small molecules that modulate amyloid formation in vitro have been identified, significant challenges remain in determining precisely how these species act. Here we describe the identification of rifamycin SV as a potent inhibitor of β(2)m fibrillogenesis when added during the lag time of a...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182555/ https://www.ncbi.nlm.nih.gov/pubmed/21873994 http://dx.doi.org/10.1038/nchembio.635 |