Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction

Cardiac magnetic resonance (CMR) offers a variety of parameters potentially suited as surrogate endpoints in clinical trials of acute myocardial infarction such as infarct size, myocardial salvage, microvascular obstruction or left ventricular volumes and ejection fraction. The present article revie...

Descripción completa

Detalles Bibliográficos
Autores principales: Desch, Steffen, Eitel, Ingo, de Waha, Suzanne, Fuernau, Georg, Lurz, Philipp, Gutberlet, Matthias, Schuler, Gerhard, Thiele, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182906/
https://www.ncbi.nlm.nih.gov/pubmed/21917147
http://dx.doi.org/10.1186/1745-6215-12-204
_version_ 1782212943247572992
author Desch, Steffen
Eitel, Ingo
de Waha, Suzanne
Fuernau, Georg
Lurz, Philipp
Gutberlet, Matthias
Schuler, Gerhard
Thiele, Holger
author_facet Desch, Steffen
Eitel, Ingo
de Waha, Suzanne
Fuernau, Georg
Lurz, Philipp
Gutberlet, Matthias
Schuler, Gerhard
Thiele, Holger
author_sort Desch, Steffen
collection PubMed
description Cardiac magnetic resonance (CMR) offers a variety of parameters potentially suited as surrogate endpoints in clinical trials of acute myocardial infarction such as infarct size, myocardial salvage, microvascular obstruction or left ventricular volumes and ejection fraction. The present article reviews each of these parameters with regard to the pathophysiological basis, practical aspects, validity, reliability and its relative value (strengths and limitations) as compared to competitive modalities. Randomized controlled trials of acute myocardial infarction which have used CMR parameters as a primary endpoint are presented.
format Online
Article
Text
id pubmed-3182906
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-31829062011-09-30 Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction Desch, Steffen Eitel, Ingo de Waha, Suzanne Fuernau, Georg Lurz, Philipp Gutberlet, Matthias Schuler, Gerhard Thiele, Holger Trials Review Cardiac magnetic resonance (CMR) offers a variety of parameters potentially suited as surrogate endpoints in clinical trials of acute myocardial infarction such as infarct size, myocardial salvage, microvascular obstruction or left ventricular volumes and ejection fraction. The present article reviews each of these parameters with regard to the pathophysiological basis, practical aspects, validity, reliability and its relative value (strengths and limitations) as compared to competitive modalities. Randomized controlled trials of acute myocardial infarction which have used CMR parameters as a primary endpoint are presented. BioMed Central 2011-09-14 /pmc/articles/PMC3182906/ /pubmed/21917147 http://dx.doi.org/10.1186/1745-6215-12-204 Text en Copyright ©2011 Desch et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Desch, Steffen
Eitel, Ingo
de Waha, Suzanne
Fuernau, Georg
Lurz, Philipp
Gutberlet, Matthias
Schuler, Gerhard
Thiele, Holger
Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction
title Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction
title_full Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction
title_fullStr Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction
title_full_unstemmed Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction
title_short Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction
title_sort cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182906/
https://www.ncbi.nlm.nih.gov/pubmed/21917147
http://dx.doi.org/10.1186/1745-6215-12-204
work_keys_str_mv AT deschsteffen cardiacmagneticresonanceimagingparametersassurrogateendpointsinclinicaltrialsofacutemyocardialinfarction
AT eitelingo cardiacmagneticresonanceimagingparametersassurrogateendpointsinclinicaltrialsofacutemyocardialinfarction
AT dewahasuzanne cardiacmagneticresonanceimagingparametersassurrogateendpointsinclinicaltrialsofacutemyocardialinfarction
AT fuernaugeorg cardiacmagneticresonanceimagingparametersassurrogateendpointsinclinicaltrialsofacutemyocardialinfarction
AT lurzphilipp cardiacmagneticresonanceimagingparametersassurrogateendpointsinclinicaltrialsofacutemyocardialinfarction
AT gutberletmatthias cardiacmagneticresonanceimagingparametersassurrogateendpointsinclinicaltrialsofacutemyocardialinfarction
AT schulergerhard cardiacmagneticresonanceimagingparametersassurrogateendpointsinclinicaltrialsofacutemyocardialinfarction
AT thieleholger cardiacmagneticresonanceimagingparametersassurrogateendpointsinclinicaltrialsofacutemyocardialinfarction

Ejemplares similares